Background: Congenital heart defects such as atrial septal defect, ventricular septal defect,
double outlet ventricles and the hypoplastic left heart syndrome as well as ischemic heart …

Introduction: Myocardial infarction followed by heart failure represents one of the major
causes of morbidity and mortality, particularly in industrialized countries. Engineering and …

Several recent basic research studies have described surgical methods for cardiac repair
using tissue cardiomyoplasty. This review summarizes recent advances in cardiac repair …

OBJECTIVES: Most tissue-engineering approaches to restore injured heart muscle result in
distortion of left ventricular geometry. In the present study we suggest seeding embryonic …

Cardiac tissue engineering aims at providing contractile heart muscle constructs for
replacement therapy in vivo. At present, most cardiac tissue engineering attempts utilize …

BACKGROUND: Cell transplantation for the regeneration of ischemic myocardium is limited
by poor graft viability and low cell retention. In ischemic cardiomyopathy, the extracellular …

Background—Cardiac tissue engineering offers the prospect of a novel treatment for
acquired or congenital heart defects. We have created vascularized pieces of beating …

Heart failure is the end-stage of many cardiovascular diseases—such as acute myocardial
infarction—and remains one of the most appealing challenges for regenerative medicine …

Children with severe congenital malformations, such as single-ventricle anomalies, have a
daunting prognosis. Heart transplantation would be a therapeutic option but is restricted due …

OBJECTIVE: Cardiac tissue engineering has been proposed as a treatment to repair
impaired hearts. Bioengineered cardiac grafts are created by combining autologous cell …