Although development of nanomedicines has been a promising direction in tumor treatment,
the therapeutic outcome of current nanomedicines is unsatisfying, partly because of the poor …

Nanocarriers are widely used for delivering drugs to tumors and are progressing in a stable
trend. The enhanced permeability and retention (EPR) effect has been a key rationale for the …

Background and purpose Nanoparticle-loaded hydrogels–localized drug delivery devices
containing a combination of therapeutic nanoparticles and implantable hydrogel–have been …

In the tumor microenvironment (TME), the extracellular matrix (ECM) produced by cancer-
associated fibroblasts (CAFs) forms a dense barrier that prevents nanodrugs from …

Despite the development of treatment options in breast cancer, many patients die of
recurrence and metastasis. Owing to enhanced permeability and retention in solid tumor …

Dense extracellular matrix (ECM) severely impedes the spread of drugs in solid tumors and
induces hypoxia, reducing chemotherapy efficiency. Different proteolytic enzymes, such as …

Aims The extracellular matrix (ECM) within the tumor nest plays a key role in cancer cell
proliferation and invasion. It has been proven that the increased density of ECM, especially …

Pancreatic ductal adenocarcinoma (PDAC), one of the worst prognosis types of tumors, is
characterized by dense extracellular matrix, which compresses tumor vessels and forms a …

Over the years, the manipulation and clinical application of drug-delivery nanosystems for
cancer diseases have attracted a rapid growth of academic research interests, and some …

The penetration of nanomedicine into solid tumor still constitutes a great challenge for
cancer therapy, which lead to the failure of thorough clearance of tumor cells. Aiming at …