Design, synthesis, molecular docking and anticancer evaluations of 5-benzylidenethiazolidine-2, 4-dione derivatives targeting VEGFR-2 enzyme

K El-Adl, AGA El-Helby, H Sakr, IH Eissa… - Bioorganic …, 2020 - Elsevier
Abstract Novel series of 5-benzylidenethiazolidine-2, 4-dione derivatives 4 ac-8 af were
designed, synthesized and evaluated for anticancer activity against HepG2, HCT-116 and …
被引用次数：77 相关文章 所有 3 个版本

Design, synthesis, molecular docking, anticancer evaluations, and in silico pharmacokinetic studies of novel 5‐[(4‐chloro/2, 4‐dichloro) benzylidene] thiazolidine‐2, 4 …

K El‐Adl, AGA El‐Helby, H Sakr, RR Ayyad… - Archiv der …, 2021 - Wiley Online Library
The anticancer activity of novel thiazolidine‐2, 4‐diones was evaluated against HepG2, HCT‐
116, and MCF‐7 cells. MCF‐7 was the most sensitive cell line to the cytotoxicity of the new …
被引用次数：49 相关文章 所有 3 个版本

5‐(4‐Methoxybenzylidene) thiazolidine‐2, 4‐dione‐derived VEGFR‐2 inhibitors: design, synthesis, molecular docking, and anticancer evaluations

K El‐Adl, H Sakr, M Nasser, M Alswah… - Archiv der …, 2020 - Wiley Online Library
Abstract A novel series of 5‐(4‐methoxybenzylidene) thiazolidine‐2, 4‐dione derivatives, 5a–
g and 7a–f, was designed, synthesized, and evaluated for their anticancer activity against …
被引用次数：40 相关文章 所有 3 个版本

Design, green synthesis, molecular docking and anticancer evaluations of diazepam bearing sulfonamide moieties as VEGFR-2 inhibitors

NM Saleh, MSA El-Gaby, K El‐Adl… - Bioorganic …, 2020 - Elsevier
Novel series of diazepam bearing sulfonamide moieties 5 af and 7 ac were designed,
synthesized and evaluated for anticancer activity against HepG2, HCT-116 and MCF-7 cell …
被引用次数：53 相关文章 所有 3 个版本

Design, synthesis, docking, ADMET profile, and anticancer evaluations of novel thiazolidine‐2, 4‐dione derivatives as VEGFR‐2 inhibitors

K El‐Adl, H Sakr, SSA El‐Hddad… - Archiv der …, 2021 - Wiley Online Library
The anticancer activity of novel thiazolidine‐2, 4‐diones was evaluated against HepG2, HCT‐
116, and MCF‐7 cells. Among the tested cancer cell lines, HCT‐116 was the most sensitive …
被引用次数：35 相关文章 所有 3 个版本
[PDF] researchgate.net

Pyridine‐derived VEGFR‐2 inhibitors: rational design, synthesis, anticancer evaluations, in silico ADMET profile, and molecular docking

NM Saleh, AAH Abdel‐Rahman, AM Omar… - Archiv der …, 2021 - Wiley Online Library
Abstract Novel pyridine‐derived compounds (5–19) were designed and synthesized, and
their anticancer activities were evaluated against HepG2 and MCF‐7 cells, targeting the …
被引用次数：29 相关文章 所有 4 个版本

Design, synthesis, molecular docking, and anticancer evaluations of 1‐benzylquinazoline‐2,4(1H,3H)‐dione bearing different moieties as VEGFR‐2 inhibitors

K El‐Adl, AGA El‐Helby, H Sakr… - Archiv der …, 2020 - Wiley Online Library
A novel series of 1‐benzylquinazoline‐2, 4 (1H, 3H)‐dione derivatives, 6a, b to 11a–e, was
designed, synthesized, and evaluated for their anticancer activity against HepG2, HCT‐116 …
被引用次数：43 相关文章 所有 3 个版本
[PDF] academia.edu

Design, synthesis, molecular docking and cytotoxic evaluation of novel 2-furybenzimidazoles as VEGFR-2 inhibitors

MA Abdullaziz, HT Abdel-Mohsen… - European journal of …, 2017 - Elsevier
Inhibition of angiogenesis through inhibition of vascular endothelial growth factor receptor 2
(VEGFR-2) has been applied in cancer therapy because of its important role in promoting …
被引用次数：97 相关文章 所有 4 个版本

Design, molecular docking, in vitro, and in vivo studies of new quinazolin-4 (3H)-ones as VEGFR-2 inhibitors with potential activity against hepatocellular carcinoma

IH Eissa, MK Ibrahim, AM Metwaly, A Belal… - Bioorganic …, 2021 - Elsevier
A series of new VEGFR-2 inhibitors were designed, synthesized and evaluated for their anti-
proliferative activities against hepatocellular carcinoma (HepG-2 cell line). Compound 29 b …
被引用次数：74 相关文章 所有 5 个版本

Design, synthesis, in vitro anti-cancer activity, ADMET profile and molecular docking of novel triazolo [3, 4-a] phthalazine derivatives targeting VEGFR-2 enzyme

AGA El-Helby, H Sakr, RRA Ayyad… - Anti-Cancer Agents …, 2018 - ingentaconnect.com
Background: Extensive studies were reported in the synthesis of several phthalazine
derivatives as promising anticancer agents as potent VEGFR-2 inhibitors. Vatalanib …
被引用次数：41 相关文章 所有 4 个版本