With the consideration of the multifactorial etiology of diabetic peripheral neuropathy, an
ideal drug or drug combination should target at least several key pathogenetic mechanisms …

The interactions among multiple pathogenetic mechanisms of diabetic peripheral
neuropathy largely remain unexplored. Increased activity of aldose reductase, the first …

Rutin exhibits antidiabetic, antioxidant and anti-inflammatory properties, which makes rutin
an attractive candidate for diabetic complications. The present study was designed to …

The mechanisms leading to diabetic neuropathy are complex. As an active component in
several traditional Chinese medicines, berberine has a beneficial effect in the treatment of …

Oxidative stress has been recognized as the contributor to diabetic peripheral neuropathy
(DPN). Antioxidant strategies have been most widely explored; nevertheless, whether …

Oxidative stress is considered a major contributor in the pathogenesis of diabetic
neuropathy and in diabetes complications, such as nephropathy and cardiovascular …

Background: Axonopathy is closely linked to the development of diabetic encephalopathy
induced by type II diabetes (T2D). Berberine has been shown to cross the blood-brain …

High glucose affects primary afferent neurons in dorsal root ganglia by inhibiting neurite
elongation, causing oxidative stress, and inducing neuronal apoptosis and mitochondrial …

Neonatal-streptozotocin (n-STZ)-induced diabetes mimics most of the clinicopathological
symptoms of type 2 diabetes mellitus (T2DM) peripheral neuropathy. Berberine, a plant …

Reactive oxygen intermediates production and apoptotic damage induced by high glucose
are major causes of neuronal damage in diabetic neuropathy. Berberine (BBR), a natural …