Peripheral detection of nociceptive and painful stimuli by sensory neurons involves a
complex repertoire of molecular detectors and/or transducers on distinct subsets of nerve …

Nociception is the process of transmission of painful signals by nociceptors in the primary
afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are …

Specialized receptors belonging to the transient receptor potential (TRP) family of ligand-
gated ion channels constitute the critical detectors and transducers of pain-causing stimuli …

Patients with inflammatory or neuropathic pain experience hypersensitivity to mechanical,
thermal and/or chemical stimuli. Given the diverse etiologies and molecular mechanisms of …

Nociception is the process whereby primary afferent nerve fibers of the somatosensory
system detect noxious stimuli. Pungent irritants from pepper, mint, and mustard plants have …

The perception of nociceptive signals, which are translated into pain, plays a fundamental
role in the survival of organisms. Because pain is linked to a negative sensation, animals …

Transient receptor potential (TRP) ion channels are molecular gateways in sensory systems,
an interface between the environment and the nervous system. Several TRPs transduce …

Pain is initiated when noxious stimuli excite the peripheral terminals of specialized primary
afferent neurons called nociceptors. Many molecules are involved in conversion of the …

The last decade has witnessed an explosion in novel findings relating to the molecules
involved in mediating the sensation of pain in humans. Transient receptor potential (TRP) …

Neuropathic pain is a chronic disease resulting from dysfunction of the nervous system often
due to peripheral nerve injury. Hypersensitivity to sensory stimuli (mechanical, thermal or …