[HTML][HTML] Chloroquine, a FDA-approved drug, prevents Zika virus infection and its associated congenital microcephaly in mice
Zika virus (ZIKV) has become a global public health emergency due to its rapidly expanding
range and its ability to cause severe congenital defects such as microcephaly. However …
range and its ability to cause severe congenital defects such as microcephaly. However …
[HTML][HTML] Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis
One of the major challenges of the current Zika virus (ZIKV) epidemic is to prevent
congenital foetal abnormalities, including microcephaly, following ZIKV infection of pregnant …
congenital foetal abnormalities, including microcephaly, following ZIKV infection of pregnant …
[HTML][HTML] Chloroquine, an endocytosis blocking agent, inhibits Zika virus infection in different cell models
R Delvecchio, LM Higa, P Pezzuto, AL Valadão… - Viruses, 2016 - mdpi.com
Zika virus (ZIKV) infection in utero might lead to microcephaly and other congenital defects.
Since no specific therapy is available thus far, there is an urgent need for the discovery of …
Since no specific therapy is available thus far, there is an urgent need for the discovery of …
Chloroquine inhibits endosomal viral RNA release and autophagy-dependent viral replication and effectively prevents maternal to fetal transmission of Zika virus
Zika virus (ZIKV) infection can cause neonatal microcephaly and neurological disorders.
Currently, there is no designated drug for treating ZIKV infection and preventing neonatal …
Currently, there is no designated drug for treating ZIKV infection and preventing neonatal …
[HTML][HTML] Antiviral agents in development for Zika virus infections
In 1947, Zika virus (ZIKV), a mosquito-borne flavivirus was identified in Uganda and
subsequently spread to Asia and the Pacific regions. In 2015, it was introduced in Brazil …
subsequently spread to Asia and the Pacific regions. In 2015, it was introduced in Brazil …
[HTML][HTML] American strain of Zika virus causes more severe microcephaly than an old Asian strain in neonatal mice
F Zhang, HJ Wang, Q Wang, ZY Liu, L Yuan… - …, 2017 - thelancet.com
Zika virus (ZIKV) has evolved from an overlooked mosquito-borne flavivirus into a global
health threat due to its astonishing causal link to microcephaly and other disorders. ZIKV has …
health threat due to its astonishing causal link to microcephaly and other disorders. ZIKV has …
[HTML][HTML] Identification of novel natural products as effective and broad-spectrum anti-Zika virus inhibitors
Zika virus (ZIKV) infection during pregnancy leads to severe congenital Zika syndrome,
which includes microcephaly and other neurological malformations. No therapeutic agents …
which includes microcephaly and other neurological malformations. No therapeutic agents …
[HTML][HTML] A screen of FDA-approved drugs for inhibitors of Zika virus infection
NJ Barrows, RK Campos, ST Powell, KR Prasanth… - Cell host & …, 2016 - cell.com
Currently there are no approved vaccines or specific therapies to prevent or treat Zika virus
(ZIKV) infection. We interrogated a library of FDA-approved drugs for their ability to block …
(ZIKV) infection. We interrogated a library of FDA-approved drugs for their ability to block …
Zika virus cell tropism in the developing human brain and inhibition by azithromycin
H Retallack, E Di Lullo, C Arias… - Proceedings of the …, 2016 - National Acad Sciences
The rapid spread of Zika virus (ZIKV) and its association with abnormal brain development
constitute a global health emergency. Congenital ZIKV infection produces a range of mild to …
constitute a global health emergency. Congenital ZIKV infection produces a range of mild to …
Evaluation of anti-Zika virus activities of broad-spectrum antivirals and NIH clinical collection compounds using a cell-based, high-throughput screen assay
Recent studies have clearly underscored the association between Zika virus (ZIKV) and
severe neurological diseases such as microcephaly and Guillain-Barre syndrome. Given the …
severe neurological diseases such as microcephaly and Guillain-Barre syndrome. Given the …