The more severe strains of the bacterial human pathogen Helicobacter pylori produce a type
IV secretion system (cagT4 SS) to inject the oncoprotein cytotoxin‐associated gene A …

Translocation of the Helicobacter pylori (Hp) cytotoxin-associated gene A (CagA) effector
protein via the cag-Type IV Secretion System (T4SS) into host cells is a major risk factor for …

CagL is an essential pilus surface component of the virulence‐associated type IV secretion
system (T4 SS) employed by Helicobacter pylori to translocate the oncogenic effector protein …

Abstract The Cag Type IV secretion system, which contributes to inflammation and
cancerogenesis during chronic infection, is one of the major virulence factors of the bacterial …

Cytotoxin-associated gene product A (CagA) is a major virulence factor secreted by
Helicobacter pylori. CagA activity in the gastric epithelium is associated with higher risk of …

Helicobacter pylori, the causative agent of type B gastritis, peptic ulcers, gastric
adenocarcinoma and MALT lymphoma, uses the Cag type IV secretion system to induce a …

Helicobacter pylori is a very successful human‐specific bacterium worldwide. Infections of
the stomach with this pathogen can induce pathologies, including chronic gastritis, peptic …

Helicobacter pylori is a highly successful human bacterium, which is exceptionally equipped
to persistently inhabit the human stomach. Colonization by this pathogen is associated with …

Intercellular junctions are crucial structural elements for the formation and maintenance of
epithelial barrier functions to control homeostasis or protect against intruding pathogens in …

Colonization of the human stomach by Helicobacter pylori is an important risk factor for
development of gastric cancer. The H. pylori cag pathogenicity island (cag PAI) encodes …