A compendium of RNA-binding motifs for decoding gene regulation

D Ray, H Kazan, KB Cook, MT Weirauch… - Nature, 2013 - nature.com
RNA-binding proteins are key regulators of gene expression, yet only a small fraction have
been functionally characterized. Here we report a systematic analysis of the RNA motifs …

Conserved structures and diversity of functions of RNA-binding proteins

CG Burd, G Dreyfuss - science, 1994 - science.org
In eukaryotic cells, a multitude of RNA-binding proteins play key roles in the
posttranscriptional regulation of gene expression. Characterization of these proteins has led …

Regulatory non-coding RNAs: everything is possible, but what is important?

JK Guo, M Guttman - nature methods, 2022 - nature.com
In recent years, the number of annotated noncoding RNAs (ncRNAs) and RNA-binding
proteins (RBPs) has increased dramatically. The wide range of RBPs identified highlights …

[HTML][HTML] A large-scale binding and functional map of human RNA-binding proteins

EL Van Nostrand, P Freese, GA Pratt, X Wang, X Wei… - Nature, 2020 - nature.com
Many proteins regulate the expression of genes by binding to specific regions encoded in
the genome 1. Here we introduce a new data set of RNA elements in the human genome …

Deciphering the role of RNA-binding proteins in the post-transcriptional control of gene expression

S Kishore, S Luber, M Zavolan - Briefings in functional genomics, 2010 - academic.oup.com
Eukaryotic cells express a large variety of ribonucleic acid-(RNA)-binding proteins (RBPs)
with diverse affinity and specificity towards target RNAs that play a crucial role in almost …

[HTML][HTML] RNA-binding proteins as regulators of gene expression

H Siomi, G Dreyfuss - Current opinion in genetics & development, 1997 - Elsevier
A plethora of post-transcriptional mechanisms are involved in essential steps in the pathway
of genetic information expression in eukaryotes. These processes are specified by cis-acting …

The kinetic landscape of an RNA-binding protein in cells

D Sharma, LL Zagore, MM Brister, X Ye… - Nature, 2021 - nature.com
Gene expression in higher eukaryotic cells orchestrates interactions between thousands of
RNA-binding proteins (RBPs) and tens of thousands of RNAs. The kinetics by which RBPs …

[HTML][HTML] Diverse RNA-binding proteins interact with functionally related sets of RNAs, suggesting an extensive regulatory system

DJ Hogan, DP Riordan, AP Gerber, D Herschlag… - PLoS …, 2008 - journals.plos.org
RNA-binding proteins (RBPs) have roles in the regulation of many post-transcriptional steps
in gene expression, but relatively few RBPs have been systematically studied. We searched …

High-throughput characterization of protein–RNA interactions

KB Cook, TR Hughes, QD Morris - Briefings in functional …, 2015 - academic.oup.com
RNA-binding proteins (RBPs) are important regulators of eukaryotic gene expression.
Genomes typically encode dozens to hundreds of proteins containing RNA-binding …

[HTML][HTML] Sequence, structure, and context preferences of human RNA binding proteins

D Dominguez, P Freese, MS Alexis, A Su, M Hochman… - Molecular cell, 2018 - cell.com
RNA binding proteins (RBPs) orchestrate the production, processing, and function of
mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an unbiased …