Objectives: Suppressor of cytokine signalling (SOCS) proteins are inhibitors of cytokine
signalling that function via the JAK/STAT pathway (Janus kinase/signal transducers and …

Osteoarthritis (OA) is a degenerative joint disease that is characterized by localized
inflammatory and secondary proliferative changes. Suppressor of cytokine signaling 3 …

Objective To determine the expression of suppressor of cytokine signaling 3 (SOCS‐3) in
human articular chondrocytes and its functional consequences. Methods Chondrocytes …

Objectives. Cytokines play a key pathogenic role in rheumatoid arthritis (RA). Several
cytokines signal through the JAK-STAT pathway, which is negatively regulated by the …

Immune and inflammatory systems are controlled by multiple cytokines, including
interleukins and interferons. Many of these cytokines exert their biological functions through …

Suppressor of cytokine signaling (SOCS) proteins are significant regulators of cellular
immune responses. Therefore, the role of SOCS in bone-inflammatory disorders, including …

Recently, Suppressor of Cytokine Signaling 1 (SOCS1) was identified as a potential
therapeutic target for osteoarthritis (OA) treatment. However, the mechanisms and signaling …

Introduction Although IL-1β is believed to be crucial in the pathogenesis of osteoarthritis
(OA), the IL-1β blockade brings no therapeutic benefit in human OA and results in OA …

Suppressor of cytokine signaling-1 (SOCS-1) is a negative regulator of cytokine signaling.
To investigate the role of SOCS-1 in regulating inflammatory and immune responses in …

Bone metabolism and the immune system have a correlative relationship, and both are
controlled by various common cytokines, such as IFNs and ILs, produced in the bone …