Extracellular ATP is a mediator of intercellular communication and a danger signal. Release
of this and other nucleotides modulates microglia responses via P2Y and P2X receptors …

To test whether extracellular ATP can play a role in the neuroimmunopathology of
Alzheimer's disease (AD), we evaluated the capacity of the ATP-binding purinoreceptor …

The expression of the purinergic receptor subtype P2X7R, a nonselective cationic channel
activated by high levels of adenosine triphosphate (ATP), has been studied in adult …

The P2X7 receptor has been implicated in the release of cytokines and in the induction of
cell death, and is up‐regulated in a transgenic mouse model of Alzheimer's disease. Using …

Activation of microglia has been implicated in many neurological conditions including
Alzheimer's disease and neuropathic pain. Recent studies provide evidence that P2X ATP …

ATP is an important regulator of microglia and its effects on microglial cytokine release are
currently discussed as important contributors in a variety of brain diseases. We here …

Microglia are the resident phagocytes of the central nervous system, and microglial
activation is considered to play an important role in the pathogenesis of neurodegenerative …

Microglia are implicated in neurodegeneration, potentially by phagocytosing neurons, but it
is unclear how to block the detrimental effects of microglia while preserving their beneficial …

P2X7 is a subtype of ATP-gated channels that is highly expressed in astrocytes, microglia,
and other immune cells. Activation of P2X7 purinoceptors by ATP or 3′-O-(4-benzoyl) …

Microglial activation is an integral part of neuroinflammation associated with many
neurodegenerative conditions. Interestingly, a number of neurodegenerative conditions …