Aim: To develop and optimize a sustained release multivesicular liposome (MVL)
formulation of interferon (IFN) α-2b. Methods: IFN α-2b MVL were prepared using a typical …

The aim of the present study was to investigate the effect of liposome-encapsulation and
liposome-size on the in vivo pharmacokinetics of interferon α-2b (IFNα-2b) following im …

Hepatitis C viral chemotherapy suffers from a relatively short half-life of the interferon α-2a
(IFN α). To address this issue, we investigated the effects of polyethylene glycol modification …

A novel modified film-hydration–dilution method was employed to prepare highly
encapsulated interferon-α-2b containing liposomes for intramuscular sustained release. The …

Interferon alpha-2b (IFNα-2b) is an important immune regulator used widely in clinic.
However, frequent subcutaneous injection and substantial toxicity decrease patients' …

Interferon-γ (IFNγ) has proven to be a promising adjuvant in vaccines against cancer and
infectious diseases. However, due to its rapid biodegradation and clearance, its efficacy is …

In this work, a new microsphere delivery system comprising calcium alginate microcores
surrounded by a biodegradable poly‐dl‐lactide‐poly (ethylene glycol)(PELA) coat was …

We encapsulated human interferon-γ (HuIFN-γ) into liposomes and analyzed whether this
preparation prevented the rapid decay of IFN-γ in the serum of C57BL/6 mice after …

Purpose: Topical biphasic vesicle delivery system encapsulating interferon alpha (IFN α)
was developed as an alternative to injections used to treat human papillomavirus (HPV) …

Gelatin microspheres (ms) and gelatin/BSA (bovine serum albumin) or gelatin/alginate ms
were prepared by encapsulating fluorescein isothiocyanate (FITC) labeled dextran or …