Although great advances in siRNA and mRNA delivery have been made (eg with lipid
nanoparticles), there remains a pressing need for a versatile platform that can deliver both …

Water-soluble temperature responsive triblock copolymers, poly (ethylene oxide)-b-poly
(acrylic acid)-b-poly (N-isopropylacrylamide)(PEO-PAA-PNIPAM), were prepared in one pot …

Synthetic nanovesicles, known as liposomes, are assembled from synthetic lipids as
encapsulation devices for delivery of small molecules and are now a key component of …

Nanocavities composed of lipids and block polymers have demonstrated great potential in
biomedical applications such as sensors, nanoreactors, and delivery vectors. However, it …

Polymersomes are polymer-based vesicular shells that form upon hydration of amphiphilic
block copolymers. These high molecular weight amphiphiles impart physicochemical …

Nanoparticles (NPs) formulated with cationic lipids and/or polymers have shown substantial
potential for systemic delivery of RNA therapeutics such as small interfering RNA (siRNA) for …

A new generation of siRNA nanocarrier with compact, uniform size and excellent colloidal
stability has been developed by combining inorganic nanoparticles with rationally designed …

Therapeutic biomacromolecules are highly specific, which results in controlled therapeutic
effect and less toxicity than small molecules. However, proteins and nucleic acids are large …

siRNA nanomedicines can potentially treat many human diseases, but safe and effective
delivery remains a challenge. DNA delivery polymers such as poly (β-amino ester) s …

Polymersomes provide a highly promising platform for mimicking biological membranes as
well as for controlled delivery of various pharmaceuticals and biopharmaceuticals. The …