Targeting inflammation as a therapeutic strategy for drug-resistant epilepsies: an update of new immune-modulating approaches
G Vitaliti, P Pavone, F Mahmood… - Human vaccines & …, 2014 - Taylor & Francis
An increasing body of literature data suggests that inflammation, and in particular
neuroinflammation, is involved in the pathophysiology of particular forms of epilepsy and …
neuroinflammation, is involved in the pathophysiology of particular forms of epilepsy and …
Immunity and inflammation in epilepsy
A Vezzani, B Lang, E Aronica - Cold Spring …, 2016 - perspectivesinmedicine.cshlp.org
This review reports the available evidence on the activation of the innate and adaptive
branches of the immune system and the related inflammatory processes in epileptic …
branches of the immune system and the related inflammatory processes in epileptic …
Modulation of immunity and the inflammatory response: a new target for treating drug-resistant epilepsy
N Yu, H Liu, Q Di - Current Neuropharmacology, 2013 - ingentaconnect.com
Until recently, epilepsy medical therapy is usually limited to anti-epileptic drugs (AEDs).
However, approximately 1/3 of epilepsy patients, described as drug-resistant epilepsy (DRE) …
However, approximately 1/3 of epilepsy patients, described as drug-resistant epilepsy (DRE) …
Experimental studies in epilepsy: immunologic and inflammatory mechanisms
A Legido, CD Katsetos - Seminars in pediatric neurology, 2014 - Elsevier
In this article, we review the literature based on experimental studies lending credence to a
relationship between epilepsy and immune-mediated mechanisms linked to central nervous …
relationship between epilepsy and immune-mediated mechanisms linked to central nervous …
Does brain inflammation mediate pathological outcomes in epilepsy?
Inflammation in the central nervous system (CNS) is associated with epilepsy and is
characterized by the increased levels of a complex set of soluble molecules and their …
characterized by the increased levels of a complex set of soluble molecules and their …
Neuroinflammatory targets and treatments for epilepsy validated in experimental models
A large body of evidence that has accumulated over the past decade strongly supports the
role of inflammation in the pathophysiology of human epilepsy. Specific inflammatory …
role of inflammation in the pathophysiology of human epilepsy. Specific inflammatory …
The role of inflammation in epilepsy
Epilepsy is the third most common chronic brain disorder, and is characterized by an
enduring predisposition to generate seizures. Despite progress in pharmacological and …
enduring predisposition to generate seizures. Despite progress in pharmacological and …
Inflammation and epilepsy: preclinical findings and potential clinical translation
G Terrone, A Salamone… - Current pharmaceutical …, 2017 - ingentaconnect.com
Background: The lack of treatments which can prevent epilepsy development or improve
disease prognosis represents an unmet and urgent clinical need. The development of such …
disease prognosis represents an unmet and urgent clinical need. The development of such …
Inflammatory pathways of seizure disorders
Epilepsy refers to a cluster of neurological diseases characterized by seizures. Although
many forms of epilepsy have a well-defined immune etiology, in other forms of epilepsy an …
many forms of epilepsy have a well-defined immune etiology, in other forms of epilepsy an …
[HTML][HTML] Immune mechanisms in epileptogenesis
D Xu, SD Miller, S Koh - Frontiers in cellular neuroscience, 2013 - frontiersin.org
Epilepsy is a chronic brain disorder that affects 1% of the human population worldwide.
Immune responses are implicated in seizure induction and the development of epilepsy. Pre …
Immune responses are implicated in seizure induction and the development of epilepsy. Pre …