Targeting inflammation as a therapeutic strategy for drug-resistant epilepsies: an update of new immune-modulating approaches

G Vitaliti, P Pavone, F Mahmood… - Human vaccines & …, 2014 - Taylor & Francis
An increasing body of literature data suggests that inflammation, and in particular
neuroinflammation, is involved in the pathophysiology of particular forms of epilepsy and …

Immunity and inflammation in epilepsy

A Vezzani, B Lang, E Aronica - Cold Spring …, 2016 - perspectivesinmedicine.cshlp.org
This review reports the available evidence on the activation of the innate and adaptive
branches of the immune system and the related inflammatory processes in epileptic …

Modulation of immunity and the inflammatory response: a new target for treating drug-resistant epilepsy

N Yu, H Liu, Q Di - Current Neuropharmacology, 2013 - ingentaconnect.com
Until recently, epilepsy medical therapy is usually limited to anti-epileptic drugs (AEDs).
However, approximately 1/3 of epilepsy patients, described as drug-resistant epilepsy (DRE) …

Experimental studies in epilepsy: immunologic and inflammatory mechanisms

A Legido, CD Katsetos - Seminars in pediatric neurology, 2014 - Elsevier
In this article, we review the literature based on experimental studies lending credence to a
relationship between epilepsy and immune-mediated mechanisms linked to central nervous …

Does brain inflammation mediate pathological outcomes in epilepsy?

KS Wilcox, A Vezzani - Issues in Clinical Epileptology: A View from the …, 2014 - Springer
Inflammation in the central nervous system (CNS) is associated with epilepsy and is
characterized by the increased levels of a complex set of soluble molecules and their …

Neuroinflammatory targets and treatments for epilepsy validated in experimental models

E Aronica, S Bauer, Y Bozzi, M Caleo, R Dingledine… - …, 2017 - Wiley Online Library
A large body of evidence that has accumulated over the past decade strongly supports the
role of inflammation in the pathophysiology of human epilepsy. Specific inflammatory …

The role of inflammation in epilepsy

A Vezzani, J French, T Bartfai, TZ Baram - Nature reviews neurology, 2011 - nature.com
Epilepsy is the third most common chronic brain disorder, and is characterized by an
enduring predisposition to generate seizures. Despite progress in pharmacological and …

Inflammation and epilepsy: preclinical findings and potential clinical translation

G Terrone, A Salamone… - Current pharmaceutical …, 2017 - ingentaconnect.com
Background: The lack of treatments which can prevent epilepsy development or improve
disease prognosis represents an unmet and urgent clinical need. The development of such …

Inflammatory pathways of seizure disorders

N Marchi, T Granata, D Janigro - Trends in neurosciences, 2014 - cell.com
Epilepsy refers to a cluster of neurological diseases characterized by seizures. Although
many forms of epilepsy have a well-defined immune etiology, in other forms of epilepsy an …

[HTML][HTML] Immune mechanisms in epileptogenesis

D Xu, SD Miller, S Koh - Frontiers in cellular neuroscience, 2013 - frontiersin.org
Epilepsy is a chronic brain disorder that affects 1% of the human population worldwide.
Immune responses are implicated in seizure induction and the development of epilepsy. Pre …