U0126 has been reported as a specific inhibitor of the ERK1/2 signaling pathway, which
plays a vital role during the osteogenic differentiation of mesenchymal stem cells (MSCs) …

Objectives: This study was carried out to reveal functions and mechanisms of MEK/ERK and
p38 pathways in chondrogenesis of rat bone marrow mesenchymal stem cells (BMSCs), and …

Bacitracin, a widely used metallopeptide antibiotic, has been reported to be locally used in
treating wounds without systemic adverse reactions. Our preliminary study showed that …

Inflammatory factors play an important role in the process of fracture healing. The influence
of interleukin (IL)‑1β, a key inflammatory factory, on new bone formation has been …

Spheroid culture systems more accurately recreate the in vivo microenvironment and are
susceptible to factors that induce differentiation. In this study, we assessed whether bone …

This study examined the effect of wild-type Smad3 gene on the osteoblastic differentiation of
rat bone marrow-derived mesenchymal stem cells in vitro. Bone marrow-derived …

Bone marrow stromal cells (BMSCs) can undergo osteogenesis when treated with an
osteogenic stimulus, which makes them a potential cell source for bone tissue engineering …

Objective To observe the effect and mechanism of wild-type Smad3 gene on the proliferation
and osteoblastic differentiation of rat bone marrow-derived mesenchymal stem cell (MSC) …

As human lifespans have increased, the incidence of osteoporosis has also increased.
Methylsulfonylmethane (MSM) affects the process of mesenchymal stem cell (MSC) …

OBJECTIVES: Bone morphogenetic protein-2 (BMP-2) is expected to be utilized to fill bone
defects and promote healing of fractures. However, it is unable to generate an adequate …