Exercise-induced antinociception is widely described in the literature, but the mechanisms
involved in this phenomenon are poorly understood. Systemic (sc) and central (it, icv) …

Abstract Muscle pain affects approximately 11–24% of the global population. Several
studies have shown that exercise is a non-pharmacological therapy to pain control. It has …

BACKGROUND: Resistance exercise (RE) is also known as strength training, and it is
performed to increase the strength and mass of muscles, bone strength, and metabolism. RE …

Physical exercise has been repeatedly associated with decreased nociceptive responses
but the underlying mechanisms have still not been fully clarified. In this study, we …

BACKGROUND: Cannabinoid agonists induce norepinephrine release in central, spinal,
and peripheral sites. Previous studies suggest an interaction between the cannabinoid and …

Diabetes is often associated with painful neuropathy. The current treatments are
symptomatic and ineffective. Cannabinoids have been proposed as promising drugs for …

Footshock stress induces both endocannabinoid mobilization and antinociception. The
present studies investigated behavioral plasticity in cannabinoid antinociceptive …

Extensive documentation exists showing that exercise induces analgesia and sedation.
Despite decades of research attempting to explicate a neurochemical basis for these …

BACKGROUND AND PURPOSE Two non‐psychoactive cannabinoids, cannabidiol (CBD)
and cannabichromene (CBC), are known to modulate in vitro the activity of proteins involved …

Exercise induces changes in mental status, particularly analgesia, sedation, anxiolysis, and
a sense of wellbeing. The mechanisms underlying these changes remain unknown. Recent …