The spleen is the largest secondary lymphoid organ, is considered the draining site for
compounds that are administered intravenously, and is therefore considered an important …

The spleen contains hematopoietic and lymphoid elements, is a primary site of
extramedullary hematopoiesis, and removes degenerate and aged red blood cells as well …

The spleen is the largest secondary immune organ in the body and is responsible for
initiating immune reactions to blood-borne antigens and for filtering the blood of foreign …

The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria
for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology …

Routine histopathology of lymphoid organs is the cornerstone in the identification of
immunotoxic and immunomodulatory compounds. Enhanced histopathology is a systematic …

Lymph nodes function as filters of tissues and tissue fluids and are sites of origin and
production of lymphocytes for normal physiological functions. As part of this normal function …

The thymus is a primary or central lymphoid organ in which T lymphocytes undergo
diffentiation and maturation autonomously within the cortex, without the need for antigenic …

The unique architecture of the spleen enables it to play a key role in the interactions
between the circulatory, reticuloendothelial and immune systems. Response to circulating …

Enhanced histopathology (EH) of the immune system is a tool that the pathologist can use to
assist in the detection of lymphoid organ lesions when evaluating a suspected …

Like the lymph node, the human spleen is a highly compartimentalized organ. Each
compartment has its own structure, cell population, and functions. These include the white …