[HTML][HTML] An insight into role of amino acids as antioxidants via NRF2 activation

MC Egbujor, OT Olaniyan, CN Emeruwa, S Saha… - Amino Acids, 2024 - Springer
Oxidative stress can affect the protein, lipids, and DNA of the cells and thus, play a crucial
role in several pathophysiological conditions. It has already been established that oxidative …

Nutritional strategies to modulate inflammation and oxidative stress pathways via activation of the master antioxidant switch Nrf2

LFMF Cardozo, LM Pedruzzi, P Stenvinkel… - Biochimie, 2013 - Elsevier
The nuclear factor E2-related factor 2 (Nrf2) plays an important role in cellular protection
against cancer, renal, pulmonary, cardiovascular and neurodegenerative diseases where …

[HTML][HTML] Bioactive compounds in oxidative stress-mediated diseases: targeting the NRF2/ARE signaling pathway and epigenetic regulation

M Thiruvengadam, B Venkidasamy, U Subramanian… - Antioxidants, 2021 - mdpi.com
Oxidative stress is a pathological condition occurring due to an imbalance between the
oxidants and antioxidant defense systems in the body. Nuclear factor E2-related factor 2 …

[PDF][PDF] Modulation of Nrf2/Keap1 pathway by dietary phytochemicals

AE Atia, A Abdullah - Int J Res Med Sci, 2014 - researchgate.net
ABSTRACT Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), also known as NFE2L2, has
emerged as a transcription factor that plays a crucial role in cellular protection against free …

[HTML][HTML] Nrf2-activating bioactive peptides exert anti-inflammatory activity through inhibition of the NF-κB pathway

F Tonolo, A Folda, V Scalcon, O Marin… - International Journal of …, 2022 - mdpi.com
Redox status and inflammation are related to the pathogenesis of the majority of diseases.
Therefore, understanding the role of specific food-derived molecules in the regulation of …

Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases

H Kumar, IS Kim, SV More, BW Kim, DK Choi - Natural product reports, 2014 - pubs.rsc.org
Covering: 2000 to 2013 Oxidative stress is the central component of chronic diseases. The
nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway …

[HTML][HTML] An overview of NRF2-activating compounds bearing α, β-unsaturated moiety and their antioxidant effects

MC Egbujor, B Buttari, E Profumo… - International Journal of …, 2022 - mdpi.com
The surge of scientific interest in the discovery of Nuclear Factor Erythroid 2 (NFE2)-Related
Factor 2 (NRF2)-activating molecules underscores the importance of NRF2 as a therapeutic …

[HTML][HTML] Food-derived pharmacological modulators of the Nrf2/ARE pathway: Their role in the treatment of diseases

F Zhao, X Ci, X Man, J Li, Z Wei, S Zhang - Molecules, 2021 - mdpi.com
Oxidative stress, which refers to unbalanced accumulation of reactive oxygen species (ROS)
levels in cells, has been linked to acute and chronic diseases. Nuclear factor erythroid 2 …

[HTML][HTML] Phytochemicals to regulate oxidative and electrophilic stress through Nrf2 activation

Y Abiko, A Toriba, Y Kumagai - Redox Experimental …, 2023 - rem.bioscientifica.com
Graphical abstract Abstract Intake of a variety of vegetables and fruit is found to be effective
in promoting health; one of the reasons for this is activation of nuclear factor erythroid 2 …

An updated patent review of Nrf2 activators (2020-present)

Z Zhao, R Dong, K Cui, Q You… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction The nuclear factor erythroid 2-related factor 2 (Nrf2) is a pivotal transcription
factor that controls the expression of numerous cytoprotective genes and regulates cellular …