Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization
J Schlessinger, AN Plotnikov, OA Ibrahimi… - Molecular cell, 2000 - cell.com
The crystal structure of a dimeric 2: 2: 2 FGF: FGFR: heparin ternary complex at 3 Å
resolution has been determined. Within each 1: 1 FGF: FGFR complex, heparin makes …
resolution has been determined. Within each 1: 1 FGF: FGFR complex, heparin makes …
Diversity does make a difference: fibroblast growth factor-heparin interactions
S Faham, RJ Linhardt, DC Rees - Current opinion in structural biology, 1998 - Elsevier
Fibroblast growth factors (FGFs) are members of a protein family with a broad range of
biological activities. The best characterized FGFs interact with two distinct extracellular …
biological activities. The best characterized FGFs interact with two distinct extracellular …
Role of heparan sulfate in fibroblast growth factor signalling: a structural view
L Pellegrini - Current opinion in structural biology, 2001 - Elsevier
Fibroblast growth factors (FGFs) are among the best-studied heparin-binding proteins, and
heparan sulfate proteoglycans regulate FGF signalling by direct molecular association with …
heparan sulfate proteoglycans regulate FGF signalling by direct molecular association with …
Towards a resolution of the stoichiometry of the fibroblast growth factor (FGF)–FGF receptor–heparin complex
The 22 members of the fibroblast growth factor (FGF) family have been implicated in cell
proliferation, differentiation, survival, and migration. They are required for both development …
proliferation, differentiation, survival, and migration. They are required for both development …
Structural specificity of heparin binding in the fibroblast growth factor family of proteins
R Raman, G Venkataraman, S Ernst… - Proceedings of the …, 2003 - National Acad Sciences
Heparin and heparan sulfate glycosaminoglycans (HSGAGs) mediate a wide variety of
complex biological processes by specifically binding proteins and modulating their …
complex biological processes by specifically binding proteins and modulating their …
Insights into the role of heparan sulphate in fibroblast growth factor signalling
NJ Harmer - Biochemical Society Transactions, 2006 - portlandpress.com
Signalling from the FGFs (fibroblast growth factors) is crucial for the correct development and
homoeostasis of a wide range of cells and tissues. The FGF/FGFR (FGF receptor) signalling …
homoeostasis of a wide range of cells and tissues. The FGF/FGFR (FGF receptor) signalling …
Fibroblast growth factor receptors 1 and 2 interact differently with heparin/heparan sulfate: implications for dynamic assembly of a ternary signaling complex
Heparan sulfate (HS) regulates the kinetics of fibroblast growth factor 2 (FGF2)-stimulated
intracellular signaling and differentially activates cell proliferation of cells expressing …
intracellular signaling and differentially activates cell proliferation of cells expressing …
Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation
Heparin is required for fibroblast growth factor (FGF) stimulation of biological responses.
Using isothermal titration lorimetry, we show that acidic FGF (aFGF) forms a complex with …
Using isothermal titration lorimetry, we show that acidic FGF (aFGF) forms a complex with …
Distinct role of 2-O-, N-, and 6-O-sulfate groups of heparin in the formation of the ternary complex with basic fibroblast growth factor and soluble FGF receptor-1
M Rusnati, D Coltrini, P Caccia, P Dellera… - Biochemical and …, 1994 - Elsevier
Interaction of basic fibroblast growth factor (bFGF) with heparan sulfate proteoglycans
(HSPGs) plays an important role in the binding of bFGF to its tyrosine kinase receptor …
(HSPGs) plays an important role in the binding of bFGF to its tyrosine kinase receptor …
Cooperative dimerization of fibroblast growth factor 1 (FGF1) upon a single heparin saccharide may drive the formation of 2: 2: 1 FGF1· FGFR2c· heparin ternary …
CJ Robinson, NJ Harmer, SJ Goodger… - Journal of biological …, 2005 - ASBMB
The related glycosaminoglycans heparin and heparan sulfate are essential for the activity of
the fibroblast growth factor (FGF) family as they form an integral part of the signaling …
the fibroblast growth factor (FGF) family as they form an integral part of the signaling …