Summary Histone H3K36 trimethylation (H3K36me3) is frequently lost in multiple cancer
types, identifying it as an important therapeutic target. Here we identify a synthetic lethal …

Precise execution of the cell division cycle is vital for all organisms. The Cyclin dependent
kinases (CDKs) are the main cell cycle drivers, however, their activities must be precisely …

Wee1 is a critical component of the G2–M cell-cycle checkpoint control and mediates cell-
cycle arrest by regulating the phosphorylation of CDC2. Inhibition of Wee1 by a selective …

Wee1 is a tyrosine kinase that phosphorylates and inactivates CDC2 and is involved in G2
checkpoint signaling. Because p53 is a key regulator in the G1 checkpoint, p53-deficient …

Inhibition of the DNA damage checkpoint kinase WEE1 potentiates genotoxic
chemotherapies by abrogating cell-cycle arrest and proper DNA repair. However, WEE1 is …

Inhibition of Wee1 is emerging as a novel therapeutic strategy for cancer, and some data
suggest that cells with dysfunctional p53 are more sensitive to Wee1 inhibition combined …

WEE1 kinase is a key molecule in maintaining G2–cell-cycle checkpoint arrest for premitotic
DNA repair. Whereas normal cells repair damaged DNA during G1-arrest, cancer cells often …

Inhibition of the protein kinase WEE1 synergizes with chemotherapy in preclinical models
and WEE1 inhibitors are being explored as potential cancer therapies. Here, we investigate …

WEE1 kinase plays a crucial role in the G2–M cell-cycle checkpoint arrest for DNA repair
before mitotic entry. Normal cells repair damaged DNA during G1 arrest; however, cancer …

Background Inhibition of kinases involved in the DNA damage response sensitizes cells to
genotoxic agents by abrogating checkpoint-induced cell cycle arrest. CHK1 and WEE1 act in …