Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III …
Background Intraventricular haemorrhage is a subtype of intracerebral haemorrhage, with
50% mortality and serious disability for survivors. We aimed to test whether attempting to …
50% mortality and serious disability for survivors. We aimed to test whether attempting to …
A multicenter, randomized, double-blinded, placebo-controlled phase III study of Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage …
Background In adults, intraventricular thrombolytic therapy with recombinant tissue
plasminogen activator (rtPA) facilitates resolution of intraventricular haemorrhage (IVH) …
plasminogen activator (rtPA) facilitates resolution of intraventricular haemorrhage (IVH) …
Alteplase versus tenecteplase for thrombolysis after ischaemic stroke (ATTEST): a phase 2, randomised, open-label, blinded endpoint study
X Huang, BK Cheripelli, SM Lloyd, D Kalladka… - The Lancet …, 2015 - thelancet.com
Background In most countries, alteplase given within 4· 5 h of onset is the only approved
medical treatment for acute ischaemic stroke. The newer thrombolytic drug tenecteplase has …
medical treatment for acute ischaemic stroke. The newer thrombolytic drug tenecteplase has …
European Stroke Organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke
E Berge, W Whiteley, H Audebert… - European stroke …, 2021 - journals.sagepub.com
Intravenous thrombolysis is the only approved systemic reperfusion treatment for patients
with acute ischaemic stroke. These European Stroke Organisation (ESO) guidelines provide …
with acute ischaemic stroke. These European Stroke Organisation (ESO) guidelines provide …
Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised …
Background Intravenous thrombolysis with alteplase bolus followed by infusion is a global
standard of care for patients with acute ischaemic stroke. We aimed to determine whether …
standard of care for patients with acute ischaemic stroke. We aimed to determine whether …
Preliminary report of the clot lysis evaluating accelerated resolution of intraventricular hemorrhage (CLEAR-IVH) clinical trial
Introduction Brain hemorrhage is the most frequent fatal form of stroke and has the highest
level of morbidity of any stroke subtype. For patients with both intracerebral hemorrhage and …
level of morbidity of any stroke subtype. For patients with both intracerebral hemorrhage and …
Comparison of tenecteplase with alteplase for the early treatment of ischaemic stroke in the Melbourne Mobile Stroke Unit (TASTE-A): a phase 2, randomised, open …
Summary Background Mobile stroke units (MSUs) equipped with a CT scanner reduce time
to thrombolytic treatment and improve patient outcomes. We tested the hypothesis that …
to thrombolytic treatment and improve patient outcomes. We tested the hypothesis that …
Extending the time window for intravenous thrombolysis in acute ischemic stroke using magnetic resonance imaging-based patient selection
P Ringleb, M Bendszus, E Bluhmki… - … Journal of Stroke, 2019 - journals.sagepub.com
Background Intravenous thrombolysis with alteplase within a time window up to 4.5 h is the
only approved pharmacological treatment for acute ischemic stroke. We studied whether …
only approved pharmacological treatment for acute ischemic stroke. We studied whether …
Off‐label intravenous thrombolysis in acute stroke
M Guillan, A Alonso‐Canovas… - European Journal of …, 2012 - Wiley Online Library
Background and purpose: Therapy for stroke with intravenous tissue plasminogen activator
(IV‐tPA) is hampered by tight licensing restrictions; some of them have been discussed in …
(IV‐tPA) is hampered by tight licensing restrictions; some of them have been discussed in …
Long-term survival after intravenous thrombolysis for ischemic stroke: a propensity score-matched cohort with up to 10-year follow-up
Background and Purpose—Intravenous thrombolysis with alteplase is one of the few
approved treatments for acute ischemic stroke; nevertheless, little is known about its long …
approved treatments for acute ischemic stroke; nevertheless, little is known about its long …