Signaling via the NFκB system
The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune
development, immune responses, inflammation, and cancer. The NFκB signaling system …
development, immune responses, inflammation, and cancer. The NFκB signaling system …
A single NFκB system for both canonical and non-canonical signaling
VFS Shih, R Tsui, A Caldwell, A Hoffmann - Cell research, 2011 - nature.com
Two distinct nuclear factor κB (NFκB) signaling pathways have been described; the
canonical pathway that mediates inflammatory responses, and the non-canonical pathway …
canonical pathway that mediates inflammatory responses, and the non-canonical pathway …
NF‐κB signaling
E O'Dea, A Hoffmann - Wiley Interdisciplinary Reviews …, 2009 - Wiley Online Library
The NF‐κB transcription factor is a critical regulator of the immune system, and is responsive
to a large number of stimuli. Different stimuli engage signaling pathways to activate NF‐κB …
to a large number of stimuli. Different stimuli engage signaling pathways to activate NF‐κB …
Lessons from mathematically modeling the NF‐κB pathway
Mathematical modeling has proved to be a critically important approach in the study of many
complex networks and dynamic systems in physics, engineering, chemistry, and biology …
complex networks and dynamic systems in physics, engineering, chemistry, and biology …
Understanding NF‐κB signaling via mathematical modeling
R Cheong, A Hoffmann, A Levchenko - Molecular systems biology, 2008 - embopress.org
Mammalian inflammatory signaling, for which NF‐κB is a principal transcription factor, is an
exquisite example of how cellular signaling pathways can be regulated to produce different …
exquisite example of how cellular signaling pathways can be regulated to produce different …
The regulatory logic of the NF-κB signaling system
E O'Dea, A Hoffmann - Cold Spring Harbor perspectives …, 2010 - cshperspectives.cshlp.org
NF-κB refers to multiple dimers of Rel homology domain (RHD) containing polypeptides,
which are controlled by a stimulus-responsive signaling system that mediates the …
which are controlled by a stimulus-responsive signaling system that mediates the …
Molecular basis of NF-κB signaling
J Napetschnig, H Wu - Annual review of biophysics, 2013 - annualreviews.org
NF-κB (nuclear factor kappa B) family transcription factors are master regulators of immune
and inflammatory processes in response to both injury and infection. In the latent state, NF …
and inflammatory processes in response to both injury and infection. In the latent state, NF …
Targeting IKK and NF-κB for therapy
JK Durand, AS Baldwin - Advances in protein chemistry and structural …, 2017 - Elsevier
In addition to regulating immune responses, the NF-κB family of transcription factors also
promotes cellular proliferation and survival. NF-κB and its activating kinase, IKK, have …
promotes cellular proliferation and survival. NF-κB and its activating kinase, IKK, have …
Crosstalk via the NF-κB signaling system
S Basak, A Hoffmann - Cytokine & growth factor reviews, 2008 - Elsevier
The nuclear factor kappaB (NF-κB) family of transcription factors consists of 15 possible
dimers whose activity is controlled by a family of inhibitor proteins, known as IκBs. A variety …
dimers whose activity is controlled by a family of inhibitor proteins, known as IκBs. A variety …
The NF-κB multidimer system model: A knowledge base to explore diverse biological contexts
The nuclear factor κB (NF-κB) system is critical for various biological functions in numerous
cell types, including the inflammatory response, cell proliferation, survival, differentiation …
cell types, including the inflammatory response, cell proliferation, survival, differentiation …