Therapeutic proteins are indispensable in the treatment of various human diseases. Despite
the many benefits of therapeutic proteins, they also exhibit diverse side effects. Therefore …

Among a broad spectrum of medical treatments, protein therapeutics holds tremendous
opportunities for the treatment of metabolic disorders, cancer, autoimmune diseases and etc …

Intracellular delivery of proteins is a promising strategy for regulating cellular behavior and
therefore has attracted interest for biomedical applications. Despite the emergence of …

To bypass the biological barriers during the drug delivery process, it is desirable to develop
smart nanoparticles (NPs) with flexible physical and chemical properties. In this study, a …

The variation of tumor microenvironments provides a tool for the construction of stimulus-
responsive nanomedicines to enhance drug delivery efficacy. Herein, the assembly of drug …

Therapeutic release from hydrogels is traditionally controlled by encapsulation within
nanoparticles; however, this strategy is limited for the release of proteins due to poor …

The development of drug delivery systems using nanoparticles as carriers for small and
large therapeutic molecules remains a rapidly growing area of research. The advantages of …

Nanocarriers have been widely employed to deliver chemotherapeutic drugs for cancer
treatment. However, the insufficient accumulation of nanoparticles in tumors is an important …

The use of enzymes as therapeutics is very promising because of their catalytic activity and
specificity. However, intracellular delivery of active enzymes is challenging due to their low …

Pluronic-based nano-carriers including bare forms that were composed of Pluronic F 68 (NC
(PF 68)) or Pluronic F 127 (NC (PF 127)), and chitosan-conjugated forms (Chito-NC (PF 68) …