Enteric controlled-release pantoprazole-loaded microparticles prepared by using eudragit S100 and poly (ε-caprolactone) blend

RP Raffin, LM Colomé, SS Guterres… - Pharmaceutical …, 2007 - Taylor & Francis
Microparticles of poly (ε-caprolactone) and of its blend with Eudragit® S100 were prepared
by emulsion/solvent evaporation technique to provide controlled release and gastro …

Pantoprazole-loaded Eudragit blended microparticles: preparation, characterization, in vitro gastro-resistance and in vivo anti-ulcer evaluation

LM Colomé, RP Raffin, DS Jornada… - Journal of drug delivery …, 2007 - Elsevier
Pantoprazole is a proton-pump inhibitor pro-drug used in the treatment of gastric ulcers and
gastro-esophageal reflux disease. Pantoprazole must be absorbed intact in the …

Development of HPMC and Eudragit S100® blended microparticles containing sodium pantoprazole

RP Raffin, LM Colomé, SE Haas… - Die Pharmazie-An …, 2007 - ingentaconnect.com
Pantoprazole is used in the treatment of acid related disorders and Helicobacter pylori
infections. It is activated inside gastric parietal cells binding irreversibly to the H+/K+ …

Preparation, characterization, and in vivo anti-ulcer evaluation of pantoprazole-loaded microparticles

RP Raffin, LM Colomé, AR Pohlmann… - European journal of …, 2006 - Elsevier
Pantoprazole is an important drug in the treatment of acid-related disorders. This work
concerns the preparation and characterization of gastro-resistant pantoprazole-loaded …

Development and in vitro evaluation of pantoprazole-loaded microspheres

T Comoglu, N Gonul, A Dogan, N Basci - Drug delivery, 2008 - Taylor & Francis
Pantoprazole is a proton pump inhibitor prodrug used in the treatment of gastric ulcers and
gastroesophageal disease. Pantoprazole must be absorbed in the gastrointestinal tract and …

Preparation of microparticles for acid-labile lansoprazole by solvent evaporation method combined with a spray drying process

WZ Sun, WJ Lin, MS Alai - Journal of Food and Drug Analysis, 2012 - jfda-online.com
The aim of this study was to develop a microparticulate delivery system for acid-labile
lansoprazole. The solvent evaporation method was employed to prepare Eudragit® RS-100 …

Agglomerates containing pantoprazole microparticles: modulating the drug release

RP Raffin, P Colombo, F Sonvico, A Rossi… - Aaps Pharmscitech, 2009 - Springer
Pantoprazole-loaded microparticles were prepared using a blend of Eudragit® S100 and
Methocel® F4M. The accelerated stability was carried out during 6 months at 40° C and 75 …

Gastro-resistant microparticles containing sodium pantoprazole: stability studies and in vivo anti-ulcer activity

RP Raffin, LM Colomé, EES Schapoval… - The Open Drug …, 2007 - benthamopen.com
The aim of the present work was to verify the in vivo capacity of pantoprazole-loaded
microparticles to protect the gastric mucosa against ulcer formation and to evaluate their …

[PDF][PDF] Soft agglomerates of pantoprazole gastro-resistant microparticles for oral administration and intestinal release

RP Raffin, P Colombo, F Sonvico… - Journal of drug …, 2007 - researchgate.net
Soft agglomerates containing pantoprazole gastro-resistant microparticles were prepared for
an oral delayed-release solid dosage form. A new technique was used to agglomerate the …

Pharmacokinetics evaluation of soft agglomerates for prompt delivery of enteric pantoprazole-loaded microparticles

RP Raffin, LM Colomé, CRD Hoffmeister… - European journal of …, 2010 - Elsevier
Soft agglomerates containing pantoprazole-loaded microparticles were developed with the
aim of prompt delivery of gastro-resistant particles. The objective was to evaluate the relative …