Longitudinal changes of CSF biomarkers in memory clinic patients

FH Bouwman, WM van der Flier, NSM Schoonenboom… - Neurology, 2007 - AAN Enterprises
Objective: In Alzheimer disease (AD), longitudinal changes of beta-amyloid1-42 (Aβ1-42),
tau, and phosphorylated tau at threonine 181 (ptau-181) in CSF have been reported in small …

CSF biomarkers predict rate of cognitive decline in Alzheimer disease

MI Kester, AE Van Der Vlies, MA Blankenstein… - Neurology, 2009 - AAN Enterprises
Objective: CSF biomarkers amyloid beta 1-42 (Aβ42), total tau (tau), and tau phosphorylated
at threonine 181 (p-tau-181) are useful diagnostic markers for Alzheimer disease (AD). Less …

Amyloid β (1–42) and phosphorylated tau in CSF as markers for early-onset Alzheimer disease

NSM Schoonenboom, YAL Pijnenburg, C Mulder… - Neurology, 2004 - AAN Enterprises
Objective: To determine the diagnostic value of CSF amyloid β (1–42)(Aβ42), CSF total tau,
and CSF tau phosphorylated at threonine-181 (Ptau-181) in early-onset Alzheimer disease …

CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings

TT Seppälä, O Nerg, AM Koivisto, J Rummukainen… - Neurology, 2012 - AAN Enterprises
Objective: To assess the relationship between Alzheimer disease (AD)–related pathologic
changes in frontal cortical brain biopsy and AD biomarkers in ventricular vs lumbar CSF, and …

CSF biomarkers in relationship to cognitive profiles in Alzheimer disease

AE Van der Vlies, NA Verwey, FH Bouwman… - Neurology, 2009 - AAN Enterprises
Objective: To investigate the relationship between CSF biomarkers and cognitive profiles in
Alzheimer disease (AD). Methods: We included 177 patients with AD. Digit Span, Visual …

CSF tau/Aβ42 ratio for increased risk of mild cognitive impairment: A follow-up study

G Li, I Sokal, JF Quinn, JB Leverenz, M Brodey… - Neurology, 2007 - AAN Enterprises
Background: Processes of Alzheimer disease (AD) likely begin years prior to the onset of
cognitive impairment (latent AD), progress though a prodromal phase of mild cognitive …

Tau and Aβ42 protein in CSF of patients with frontotemporal degeneration

M Riemenschneider, S Wagenpfeil, J Diehl… - Neurology, 2002 - AAN Enterprises
Background: CSF concentrations of tau and β-amyloid protein-42 (Aβ42) have been
extensively studied in AD. Few data are available concerning CSF levels of both proteins in …

Cerebrospinal fluid markers for differential dementia diagnosis in a large memory clinic cohort

NSM Schoonenboom, FE Reesink, NA Verwey… - Neurology, 2012 - AAN Enterprises
Objective: To determine how amyloid β 42 (Aβ42), total tau (t-tau), and phosphorylated tau
(p-tau) levels in CSF behave in a large cohort of patients with different types of dementia …

CSF biomarker levels in early and late onset Alzheimer's disease

FH Bouwman, NSM Schoonenboom, NA Verwey… - Neurobiology of …, 2009 - Elsevier
OBJECTIVE: To compare CSF levels of beta-amyloid 1–42 (Aβ1–42), total tau (tau) and tau
phosphorylated at threonine 181 (ptau-181) between AD patients and controls according to …

CSF biomarkers predict a more malignant outcome in Alzheimer disease

AK Wallin, K Blennow, H Zetterberg, E Londos… - Neurology, 2010 - AAN Enterprises
Objective: To investigate if patterns of CSF biomarkers (T-tau, P-tau, and Aβ42) can predict
cognitive progression, outcome of cholinesterase inhibitor (ChEI) treatment, and mortality in …