The role of the complement factor H‐related (FHR) proteins in homeostasis, pathogen
defense, and autoimmune disease has recently attracted considerable interest. We highlight …

Factor H (FH) is a key alternative pathway regulator that controls complement activation both
in the fluid phase and on specific cell surfaces, thus allowing the innate immune response to …

This chapter provides an overview of the state of knowledge of the set of five complement
factor H-related proteins (CFHRs) in humans. A brief description is included of their …

The complement system responds very quickly to danger due to the eternal vigilance of its
alternative pathway (AP). In the AP, an always-on positive-feedback C3b-amplification loop …

Human complement factor H (CFH) plays a central role in regulating activated C3b to protect
host cells. CFH contain 20 short complement regulator (SCR) domains and eight N …

Factor H-related (FHR) proteins consist of varying number of complement control protein
domains that display various degrees of sequence identity to respective domains of the …

Factor H (FH) is an abundant regulator of complement activation and protects host cells from
self-attack by complement. Here we provide insight into the regulatory activity of FH by …

Homozygous deletion of a 84-kb genomic fragment in human chromosome 1 that
encompasses the CFHR1 and CFHR3 genes represents a risk factor for hemolytic uremic …

Complement factor H-related protein 1 (CFHR1) is a complement regulator which has been
reported to regulate complement by blocking C5 convertase activity and interfering with C5b …

Human complement factor H-related protein (CFHR) 4 belongs to the factor H family of
plasma glycoproteins that are composed of short consensus repeat (SCR) domains …