Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK,ACh channels in patients with chronic atrial fibrillation
N Voigt, A Friedrich, M Bock, E Wettwer… - Cardiovascular …, 2007 - academic.oup.com
Objective: In chronic atrial fibrillation (cAF) the potassium current IK, ACh develops agonist-
independent constitutive activity. We hypothesized that abnormal phosphorylation …
independent constitutive activity. We hypothesized that abnormal phosphorylation …
The G Protein–Gated Potassium Current IK,ACh Is Constitutively Active in Patients With Chronic Atrial Fibrillation
Background—The molecular mechanism of increased background inward rectifier current (I
K1) in atrial fibrillation (AF) is not fully understood. We tested whether constitutively active …
K1) in atrial fibrillation (AF) is not fully understood. We tested whether constitutively active …
Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation
N Voigt, N Rozmaritsa, A Trausch, T Zimniak… - Naunyn-Schmiedeberg's …, 2010 - Springer
Inward rectifier potassium currents I K1 and acetylcholine activated IK, ACh are implicated in
atrial fibrillation (AF) pathophysiology. In chronic AF (cAF), IK, ACh develops a receptor …
atrial fibrillation (AF) pathophysiology. In chronic AF (cAF), IK, ACh develops a receptor …
Changes in IK,ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes
Aims Although atrial tachycardia (AT) remodelling promotes agonist-independent,
constitutively active, acetylcholine-regulated K+-current (IK, ACh) that increases …
constitutively active, acetylcholine-regulated K+-current (IK, ACh) that increases …
[HTML][HTML] Impaired Na+-dependent regulation of acetylcholine-activated inward-rectifier K+ current modulates action potential rate dependence in patients with chronic …
Shortened action-potential duration (APD) and blunted APD rate adaptation are hallmarks of
chronic atrial fibrillation (cAF). Basal and muscarinic (M)-receptor-activated inward-rectifier …
chronic atrial fibrillation (cAF). Basal and muscarinic (M)-receptor-activated inward-rectifier …
Differential protein kinase C isoform regulation and increased constitutive activity of acetylcholine-regulated potassium channels in atrial remodeling
Rationale: Atrial fibrillation (AF) causes atrial-tachycardia remodeling (ATR), with enhanced
constitutive acetylcholine-regulated K+ current (IKAChC) contributing to action potential …
constitutive acetylcholine-regulated K+ current (IKAChC) contributing to action potential …
Effects of a Highly Selective Acetylcholine-Activated K+ Channel Blocker on Experimental Atrial Fibrillation
T Machida, N Hashimoto, I Kuwahara… - Circulation …, 2011 - Am Heart Assoc
Background—The acetylcholine-activated K+ current (IK, ACh) is a novel candidate for atrial-
specific antiarrhythmic therapy. The present study investigates the involvement of IK, ACh in …
specific antiarrhythmic therapy. The present study investigates the involvement of IK, ACh in …
Molecular Basis of Downregulation of G-Protein–Coupled Inward Rectifying K+ Current (IK,ACh) in Chronic Human Atrial Fibrillation: Decrease in GIRK4 mRNA Correlates With Reduced …
D Dobrev, E Graf, E Wettwer, HM Himmel, O Hala… - Circulation, 2001 - Am Heart Assoc
Background Clinical and experimental evidence suggest that the parasympathetic nervous
system is involved in the pathogenesis of atrial fibrillation (AF). However, it is unclear …
system is involved in the pathogenesis of atrial fibrillation (AF). However, it is unclear …
Enhanced Ca2+-Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation
Background: Small-conductance Ca2+-activated K+ (SK)–channel inhibitors have
antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel …
antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel …
Muscarinic type-1 receptors contribute to IK, ACh in human atrial cardiomyocytes and are upregulated in patients with chronic atrial fibrillation
J Heijman, D Kirchner, F Kunze, EM Chrétien… - International journal of …, 2018 - Elsevier
Background Basal and acetylcholine-gated inward-rectifier K+-currents (I K1 and IK, ACh,
respectively) are altered in atrial fibrillation (AF). G i-protein-coupled muscarinic (M) …
respectively) are altered in atrial fibrillation (AF). G i-protein-coupled muscarinic (M) …