Investigational NMDA receptor modulators for depression
B Szewczyk, A Pałucha-Poniewiera… - Expert Opinion on …, 2012 - Taylor & Francis
Introduction: With regards to depression, the role of N-methyl-D-aspartate receptor (NMDA)
was pursued many years ago, mainly in the form of preclinical studies. Since then, there …
was pursued many years ago, mainly in the form of preclinical studies. Since then, there …
[HTML][HTML] NMDA receptor antagonists for treatment of depression
Z Ates-Alagoz, A Adejare - Pharmaceuticals, 2013 - mdpi.com
Depression is a psychiatric disorder that affects millions of people worldwide. Individuals
battling this disorder commonly experience high rates of relapse, persistent residual …
battling this disorder commonly experience high rates of relapse, persistent residual …
N-Methyl-d-Aspartate (NMDA) Antagonists for the Treatment of Depression
Depression is a major public health concern that affects∼ 5% of the population in
industrialized societies in any given year. Drugs that increase the synaptic availability of …
industrialized societies in any given year. Drugs that increase the synaptic availability of …
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression
Context Existing therapies for major depression have a lag of onset of action of several
weeks, resulting in considerable morbidity. Exploring pharmacological strategies that have …
weeks, resulting in considerable morbidity. Exploring pharmacological strategies that have …
[PDF][PDF] NMDA receptor antagonists for depression: critical considerations
BACKGROUND: Research studies suggest that glutamate dysfunction, in particular N-
methyl-d-aspartate receptors (NMDARs) abnormalities, may be involved in the …
methyl-d-aspartate receptors (NMDARs) abnormalities, may be involved in the …
The Role of Noncompetitive Antagonists of the N‐Methyl‐d‐aspartate (NMDA) Receptors in Treatment‐Resistant Depression
Emerging evidence indicates that non‐monominergic drugs could hold promise as novel
antidepressants, particularly in the case of treatment resistance. Particular attention has …
antidepressants, particularly in the case of treatment resistance. Particular attention has …
An update on NMDA antagonists in depression
B Pochwat, G Nowak, B Szewczyk - Expert review of …, 2019 - Taylor & Francis
Introduction: Current antidepressant therapies exhibit low therapeutic efficiency and delayed
onset of antidepressant action. Thus, the search for better acting agents is a continuous …
onset of antidepressant action. Thus, the search for better acting agents is a continuous …
NMDA antagonists under investigation for the treatment of major depressive disorder
B Pochwat, A Pałucha-Poniewiera… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Mood disorders, including depression, are becoming increasingly prevalent in
the developed world. Furthermore, treatment of depression therapeutics, mainly influencing …
the developed world. Furthermore, treatment of depression therapeutics, mainly influencing …
A Randomized Trial of the N-Methyl-d-Aspartate Receptor Glycine Site Antagonist Prodrug 4-Chlorokynurenine in Treatment-Resistant Depression
Background Ketamine has rapid-acting antidepressant effects but is associated with
psychotomimetic and other adverse effects. A 7-chlorokynurenic acid is a potent and specific …
psychotomimetic and other adverse effects. A 7-chlorokynurenic acid is a potent and specific …
[HTML][HTML] ON or OFF?: modulating the N-methyl-D-aspartate receptor in major depression
SY Chan, E Matthews, PWJ Burnet - Frontiers in molecular …, 2017 - frontiersin.org
Since the discovery that a single dose of ketamine, an N-methyl-D-aspartate receptor
(NMDAR) antagonist, had rapid and long-lasting antidepressant effects, there has been …
(NMDAR) antagonist, had rapid and long-lasting antidepressant effects, there has been …