An octamer of histone proteins wraps about 200 bp of DNA into two superhelical turns to
form nucleosomes found in chromatin. Although the static structure of the nucleosomal core …

Nucleosomes are elementary building blocks of chromatin in eukaryotes. They tightly
wrap∼ 147 DNA base pairs around an octamer of histone proteins. How nucleosome …

Little is known about the roles of histone tails in modulating nucleosomal DNA accessibility
and its recognition by other macromolecules. Here we generate extensive atomic level …

Förster resonance energy transfer was used to monitor the dynamic conformations of
mononucleosomes under different chromatin folding conditions to elucidate the role of the …

The structural unit of eukaryotic chromatin is a nucleosome, comprising two histone
H2A/H2B heterodimers and one histone (H3/H4) 2 tetramer, wrapped around by∼ 146-bp …

Meters of DNA wrap around histone proteins to form nucleosomes and fit inside the micron-
diameter nucleus. For the genetic information encoded in the DNA to become available for …

Nucleosomes form the fundamental building blocks of chromatin. Subtle modifications of the
constituent histone tails mediate chromatin stability and regulate gene expression. For this …

A coarse-grained model of the nucleosome is introduced to investigate the dynamics of force-
induced unwrapping of DNA from histone octamers. In this model, the DNA is treated as a …

Genomic DNA is packaged in chromatin, a dynamic fiber variable in size and compaction. In
chromatin, repeating nucleosome units wrap 145–147 DNA basepairs around histone …

The nucleosome complex of DNA wrapped around a histone protein octamer organizes the
genome of eukaryotes and regulates the access of protein factors to the DNA. We performed …