Coupling between histone conformations and DNA geometry in nucleosomes on a microsecond timescale: atomistic insights into nucleosome functions
An octamer of histone proteins wraps about 200 bp of DNA into two superhelical turns to
form nucleosomes found in chromatin. Although the static structure of the nucleosomal core …
form nucleosomes found in chromatin. Although the static structure of the nucleosomal core …
[HTML][HTML] Histone dynamics mediate DNA unwrapping and sliding in nucleosomes
GA Armeev, AS Kniazeva, GA Komarova… - Nature …, 2021 - nature.com
Nucleosomes are elementary building blocks of chromatin in eukaryotes. They tightly
wrap∼ 147 DNA base pairs around an octamer of histone proteins. How nucleosome …
wrap∼ 147 DNA base pairs around an octamer of histone proteins. How nucleosome …
[HTML][HTML] Binding of regulatory proteins to nucleosomes is modulated by dynamic histone tails
Little is known about the roles of histone tails in modulating nucleosomal DNA accessibility
and its recognition by other macromolecules. Here we generate extensive atomic level …
and its recognition by other macromolecules. Here we generate extensive atomic level …
[HTML][HTML] Clipping of flexible tails of histones H3 and H4 affects the structure and dynamics of the nucleosome
NP Nurse, I Jimenez-Useche, IT Smith, C Yuan - Biophysical journal, 2013 - cell.com
Förster resonance energy transfer was used to monitor the dynamic conformations of
mononucleosomes under different chromatin folding conditions to elucidate the role of the …
mononucleosomes under different chromatin folding conditions to elucidate the role of the …
Histone tail network and modulation in a nucleosome
Y Tsunaka, A Furukawa, Y Nishimura - Current Opinion in Structural …, 2022 - Elsevier
The structural unit of eukaryotic chromatin is a nucleosome, comprising two histone
H2A/H2B heterodimers and one histone (H3/H4) 2 tetramer, wrapped around by∼ 146-bp …
H2A/H2B heterodimers and one histone (H3/H4) 2 tetramer, wrapped around by∼ 146-bp …
Molecular mechanism of spontaneous nucleosome unraveling
D Winogradoff, A Aksimentiev - Journal of molecular biology, 2019 - Elsevier
Meters of DNA wrap around histone proteins to form nucleosomes and fit inside the micron-
diameter nucleus. For the genetic information encoded in the DNA to become available for …
diameter nucleus. For the genetic information encoded in the DNA to become available for …
[HTML][HTML] Multiscale modeling of nucleosome dynamics
Nucleosomes form the fundamental building blocks of chromatin. Subtle modifications of the
constituent histone tails mediate chromatin stability and regulate gene expression. For this …
constituent histone tails mediate chromatin stability and regulate gene expression. For this …
[HTML][HTML] Dynamics of forced nucleosome unraveling and role of nonuniform histone-DNA interactions
IV Dobrovolskaia, G Arya - Biophysical journal, 2012 - cell.com
A coarse-grained model of the nucleosome is introduced to investigate the dynamics of force-
induced unwrapping of DNA from histone octamers. In this model, the DNA is treated as a …
induced unwrapping of DNA from histone octamers. In this model, the DNA is treated as a …
[HTML][HTML] Histone tails cooperate to control the breathing of genomic nucleosomes
J Huertas, HR Schöler, V Cojocaru - PLoS computational biology, 2021 - journals.plos.org
Genomic DNA is packaged in chromatin, a dynamic fiber variable in size and compaction. In
chromatin, repeating nucleosome units wrap 145–147 DNA basepairs around histone …
chromatin, repeating nucleosome units wrap 145–147 DNA basepairs around histone …
[HTML][HTML] Dissecting DNA-histone interactions in the nucleosome by molecular dynamics simulations of DNA unwrapping
R Ettig, N Kepper, R Stehr, G Wedemann, K Rippe - Biophysical journal, 2011 - cell.com
The nucleosome complex of DNA wrapped around a histone protein octamer organizes the
genome of eukaryotes and regulates the access of protein factors to the DNA. We performed …
genome of eukaryotes and regulates the access of protein factors to the DNA. We performed …
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