Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas
RAS Santos, ACS e Silva, C Maric… - Proceedings of the …, 2003 - National Acad Sciences
The renin–angiotensin system plays a critical role in blood pressure control and body fluid
and electrolyte homeostasis. Besides angiotensin (Ang) II, other Ang peptides, such as Ang …
and electrolyte homeostasis. Besides angiotensin (Ang) II, other Ang peptides, such as Ang …
Angiotensin (1-7) induces MAS receptor internalization
Angiotensin (Ang)(1-7) is the endogenous ligand for the G protein–coupled receptor Mas, a
receptor associated with cardiac, renal, and cerebral protective responses. Physiological …
receptor associated with cardiac, renal, and cerebral protective responses. Physiological …
Angiotensin metabolites can stimulate receptors of the Mas-related genes family
F Gembardt, S Grajewski, M Vahl… - Molecular and cellular …, 2008 - Springer
The Mas protooncogene encodes a G protein-coupled receptor, we identified, also by using
the specific angiotensin-(1-7) antagonist A-779, to be associated with intracellular signaling …
the specific angiotensin-(1-7) antagonist A-779, to be associated with intracellular signaling …
New components of the renin-angiotensin system: alamandine and the MAS-related G protein-coupled receptor D
GM Etelvino, AAB Peluso, RAS Santos - Current hypertension reports, 2014 - Springer
The renin-angiotensin system is an important component of the central and humoral
mechanisms of blood pressure and hydro-electrolytic balance control. Angiotensin II is a key …
mechanisms of blood pressure and hydro-electrolytic balance control. Angiotensin II is a key …
Endothelial dysfunction through genetic deletion or inhibition of the G protein-coupled receptor Mas: a new target to improve endothelial function
C Peiró, S Vallejo, F Gembardt, V Azcutia… - Journal of …, 2007 - journals.lww.com
Background Endothelial dysfunction is an initial step in the pathogenesis of cardiovascular
diseases. Since we previously identified the G protein-coupled receptor Mas as a receptor …
diseases. Since we previously identified the G protein-coupled receptor Mas as a receptor …
The endothelium-dependent vasodilator effect of the nonpeptide Ang (1-7) mimic AVE 0991 is abolished in the aorta of mas-knockout mice
Recently, we demonstrated that the endothelium-dependent vasodilator effect of angiotensin
(1-7) in the mouse aorta is abolished by genetic deletion of the G protein-coupled receptor …
(1-7) in the mouse aorta is abolished by genetic deletion of the G protein-coupled receptor …
G-protein–coupled receptor MrgD is a receptor for angiotensin-(1–7) involving adenylyl cyclase, cAMP, and phosphokinase a
A Tetzner, K Gebolys, C Meinert, S Klein, A Uhlich… - …, 2016 - Am Heart Assoc
Angiotensin (Ang)-(1–7) has cardiovascular protective effects and is the opponent of the
often detrimental Ang II within the renin–angiotensin system. Although it is well accepted that …
often detrimental Ang II within the renin–angiotensin system. Although it is well accepted that …
G-protein–coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor
E Kostenis, G Milligan, A Christopoulos… - Circulation, 2005 - Am Heart Assoc
Background—We previously identified the G-protein–coupled receptor Mas, encoded by the
Mas proto-oncogene, as an endogenous receptor for the heptapeptide angiotensin-(1-7); …
Mas proto-oncogene, as an endogenous receptor for the heptapeptide angiotensin-(1-7); …
Angiotensin‐(1‐7) and its effects in the kidney
Angiotensin‐(1‐7)(Ang‐[1‐7]) is a heptapeptide member of the renin‐angiotensin system
(RAS), and acts as a vasodilator and antagonist of angiotensin II (Ang II) in the vasculature …
(RAS), and acts as a vasodilator and antagonist of angiotensin II (Ang II) in the vasculature …
Evidence for a new angiotensin-(1–7) receptor subtype in the aorta of Sprague–Dawley rats
DMR Silva, HR Vianna, SF Cortes… - Peptides, 2007 - Elsevier
We have recently described, in the mouse aorta, the vasodilator effect of angiotensin-(1–
7)(Ang-(1–7)) was mediated by activation of the Mas Ang-(1–7) receptor and that A-779 and …
7)(Ang-(1–7)) was mediated by activation of the Mas Ang-(1–7) receptor and that A-779 and …