Zika virus infects newborn monocytes without triggering a substantial cytokine response

FSY Yoshikawa, AJ Pietrobon… - The Journal of …, 2019 - academic.oup.com
Zika virus (ZIKV) is a clinically important flavivirus that can cause neurological disturbances
in newborns. Here, we investigated comparatively the outcome of in vitro infection of …

Zika virus infects human blood mononuclear cells

CV Messias, JP Lemos, DP Cunha… - BMC Infectious …, 2019 - Springer
Background Zika virus (ZIKV) infection gained public health concern after the 2015 outbreak
in Brazil, when microcephaly rates increased in babies born from infected mothers. It was …

Asian Zika virus strains target CD14+ blood monocytes and induce M2-skewed immunosuppression during pregnancy

SS Foo, W Chen, Y Chan, JW Bowman, LC Chang… - Nature …, 2017 - nature.com
Blood CD14+ monocytes are frontline immunomodulators categorized into classical,
intermediate or non-classical subsets, and subsequently differentiated into M1 pro-or M2 …

CD14+CD16+ monocytes are the main target of Zika virus infection in peripheral blood mononuclear cells in a paediatric study in Nicaragua

D Michlmayr, P Andrade, K Gonzalez… - Nature …, 2017 - nature.com
The recent Zika pandemic in the Americas is linked to congenital birth defects and Guillain–
Barré syndrome. White blood cells (WBCs) play an important role in host immune responses …

Zika virus in the eye of the cytokine storm

C Maucourant, GAN Queiroz, A Samri… - European Cytokine …, 2019 - Springer
Zika virus (ZIKV) is an emerging arbovirus that causes a mosquito-borne disease. Although
infection with ZIKV generally leads to mild disease, its recent emergence in the Americas …

Asian and African lineage Zika viruses show differential replication and innate immune responses in human dendritic cells and macrophages

P Österlund, M Jiang, V Westenius, S Kuivanen… - Scientific reports, 2019 - nature.com
Zika virus (ZIKV) infections in humans are considered to be mild or subclinical. However,
during the recent epidemics in the Pacific Islands and the Americas, the infection was …

Zika virus replication in myeloid cells during acute infection is vital to viral dissemination and pathogenesis in a mouse model

EM McDonald, J Anderson, J Wilusz, GD Ebel… - Journal of …, 2020 - Am Soc Microbiol
Zika virus (ZIKV) can establish infection in immune privileged sites such as the testes, eye,
and placenta. Whether ZIKV infection of white blood cells is required for dissemination of the …

Zika virus infection preferentially counterbalances human peripheral monocyte and/or NK cell activity

FM Lum, D Lee, TK Chua, JJL Tan, CYP Lee, X Liu… - MSphere, 2018 - Am Soc Microbiol
Zika virus (ZIKV) has reemerged in the population and caused unprecedented global
outbreaks. Here, the transcriptomic consequences of ZIKV infection were studied …

Zika virus targets blood monocytes

KA Jurado, A Iwasaki - Nature Microbiology, 2017 - nature.com
Two studies identify circulating monocytes as the primary cellular target of Zika virus
infection in human blood. Monocytes are an ideal target as they have the potential to be …

Zika virus infects human fetal brain microglia and induces inflammation

FM Lum, DKS Low, Y Fan, JJL Tan… - Clinical Infectious …, 2017 - academic.oup.com
Background. The unprecedented reemergence of Zika virus (ZIKV) has startled the world
with reports of increased microcephaly in Brazil. ZIKV can infect human neural progenitors …