Chemotherapy‐associated memory deficits in adults are prevalent with systemic treatment
utilizing 5‐fluorouracil (5‐Fu). 5‐Fu disrupts cell proliferation and readily crosses the blood …

Chemotherapy has been reported to produce cognitive impairments in a significant number
of cancer patients. These deficits frequently involve aspects of spatial or declarative memory …

Fluorouracil (5-Fu) is commonly used chemotherapy drug, but it can lead to the impairment
of cognitive function. The pathogenesis of this injury is unknown but may involve …

Background In this study, we examined the effects of cyclophosphamide, methothrexate, and
5-Fluorouracil (CMF) drug combination on various aspects of learning and memory. We also …

Abstract Aims Treatment with 5-fluorouracil (5-FU) can cause impairment to adult
hippocampal neurogenesis, resulting in cognitive deficits. As melatonin has been shown to …

5-Fluorouracil (5-FU) is a cytostatic drug associated with chemotherapy-induced cognitive
impairments that many cancer patients experience after treatment. Previous work in rodents …

In patients, cancer and treatments provoke cognitive impairments referred to “chemofog”.
Here a validated neurobehavioral animal model, the unique way to explore causal direct …

5-Bromo-2′-deoxyuridine (BrdU) is frequently used as a mitotic marker in studies of cell
proliferation. Recent studies have reported cytotoxic effects of BrdU on neural progenitor …

The chemotherapy drug, 5-fluorouracil (5-FU), has been reported to cause cognitive
impairments in cancer patients. The drug also reduces cell proliferation and survival in the …

Chemotherapeutic agents produce persistent difficulties in memory through an unknown
mechanism. We tested the hypothesis that chemotherapeutic agents readily able to cross …