Correlative approaches are a powerful tool in the investigation of biological samples, but
require specific preparation procedures to maintain the strength of the employed methods …

The assessment of neuronal number, spatial organization and connectivity is fundamental
for a complete understanding of brain function. However, the evaluation of the three …

The assessment of three-dimensional (3D) brain cytoarchitecture at a cellular resolution
remains a great challenge in the field of neuroscience and constant development of imaging …

Minimally invasive deep brain neurosurgical interventions require a profound knowledge of
the morphology of the human brain. Generic brain atlases are based on histology including …

The biomedically focused brain research is largely performed on laboratory mice
considering a high homology between the human and mouse genomes. A brain has an …

Methods for resolving the three-dimensional (3D) microstructure of the brain typically start by
thinly slicing and staining the brain, followed by imaging numerous individual sections with …

Imaging modalities including magnetic resonance imaging and X-ray computed tomography
are established methods in daily clinical diagnosis of human brain. Clinical equipment does …

Histological examination achieves sub-micrometer resolution laterally. In the third
dimension, however, resolution is limited to section thickness. In addition, histological …

Three-dimensional biological microscopy presents a trade-off between spatial resolution
and field of view. Correlative approaches applying multiple imaging techniques to the same …

The spread of microtomography as a tool for visualization of soft tissues has had a
significant impact on a better understanding of complex biological systems. This technique …