[HTML][HTML] Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo [S]

CJ Pynn, NG Henderson, H Clark, G Koster… - Journal of lipid …, 2011 - ASBMB
Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-
choline) pathway in rat liver generates predominantly mono-and di-unsaturated molecular …

[HTML][HTML] Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway

CJ DeLong, YJ Shen, MJ Thomas, Z Cui - Journal of Biological Chemistry, 1999 - ASBMB
In addition to the CDP-choline pathway for phosphatidylcholine (PC) synthesis, the liver has
a unique phosphatidylethanolamine (PE) methyltransferase activity for PC synthesis via …

Kinetic analyses of liver phosphatidylcholine and phosphatidylethanolamine biosynthesis using 13C NMR spectroscopy

NV Reo, M Adinehzadeh, BD Foy - … et Biophysica Acta (BBA)-Molecular and …, 2002 - Elsevier
Choline and ethanolamine are substrates for de novo synthesis of phosphatidylcholine
(PtdC) and phosphatidylethanolamine (PtdE) through the CDP-choline and CDP …

[HTML][HTML] Insights into the requirement of phosphatidylcholine synthesis for liver function in mice

AA Noga, DE Vance - Journal of lipid research, 2003 - ASBMB
Phosphatidylcholine (PC) is made in the liver by the CDP-choline pathway and via
phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the conversion of …

[PDF][PDF] The unique acyl chain specificity of biliary phosphatidylcholines in mice is independent of their biosynthetic origin in the liver

LB Agellon, CJ Walkey, DE Vance, F Kuipers… - …, 1999 - Wiley Online Library
The liver synthesizes phosphatidylcholine (PC) de novo from choline via the CDP‐choline
pathway, and from phosphatidylethanolamine (PE) via the phosphatidylethanolamine N …

[HTML][HTML] The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease

JN van der Veen, JP Kennelly, S Wan, JE Vance… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are the most abundant
phospholipids in all mammalian cell membranes. In the 1950s, Eugene Kennedy and co …

Excess S‐adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis

M Martínez‐Uña, M Varela‐Rey, A Cano… - …, 2013 - Wiley Online Library
Methionine adenosyltransferase 1A (MAT1A) and glycine N‐methyltransferase (GNMT) are
the primary genes involved in hepatic S‐adenosylmethionine (SAMe) synthesis and …

Quantitative profiling of PE, MMPE, DMPE, and PC lipid species by multiple precursor ion scanning: a tool for monitoring PE metabolism

M Bilgin, DF Markgraf, E Duchoslav, J Knudsen… - … et Biophysica Acta (BBA …, 2011 - Elsevier
We report a method for the simultaneous identification and quantification of
phosphatidylethanolamine (PE), monomethyl-phosphatidylethanolamine (MMPE), dimethyl …

[HTML][HTML] Phosphatidylethanolamine-N-methyltransferase activity and dietary choline regulate liver-plasma lipid flux and essential fatty acid metabolism in mice

SM Watkins, X Zhu, SH Zeisel - The Journal of nutrition, 2003 - Elsevier
Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of
phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one of the two …

Hexadecylphosphocholine inhibits phosphatidylcholine biosynthesis and the proliferation of HepG2 cells

JM Jiménez‐López, MP Carrasco… - European journal of …, 2002 - Wiley Online Library
Hexadecylphosphocholine (HePC) is a synthetic lipid representative of a new group of
antiproliferative agents, alkylphosphocholines (APC), which are promising candidates in …