Development and evaluation of a secondary reference panel for BCR-ABL1 quantification on the International Scale

NCP Cross, HE White, T Ernst, L Welden, C Dietz… - Leukemia, 2016 - nature.com
Molecular monitoring of chronic myeloid leukemia patients using robust BCR-ABL1 tests
standardized to the International Scale (IS) is key to proper disease management, especially …

Establishment and validation of analytical reference panels for the standardization of quantitative BCR-ABL1 measurements on the international scale

HE White, J Hedges, I Bendit, S Branford… - Clinical …, 2013 - academic.oup.com
BACKGROUND Current guidelines for managing Philadelphia-positive chronic myeloid
leukemia include monitoring the expression of the BCR-ABL1 (breakpoint cluster region/c …

[HTML][HTML] Molecular monitoring of chronic myeloid leukemia: international standardization of BCR-ABL1 quantitation

CJ Zhen, YL Wang - The Journal of Molecular Diagnostics, 2013 - Elsevier
The BCR-ABL1 translocation is a hallmark of chronic myeloid leukemia. Because patients
treated with imatinib and other tyrosine kinase inhibitors achieve lower levels of detectable …

Molecular monitoring of chronic myeloid leukemia: principles and interlaboratory standardization

NCP Cross, A Hochhaus, MC Müller - Annals of hematology, 2015 - Springer
Serial quantification of BCR-ABL1 messenger RNA (mRNA) is an important therapeutic
indicator for patients with chronic myeloid leukemia, but historically, there has been …

A review of the challenge in measuring and standardizing BCR-ABL1

S Yu, M Cui, X He, R Jing, H Wang - Clinical Chemistry and …, 2017 - degruyter.com
Breakpoint cluster region-Abelson (BCR-ABL1) translocation is the characteristic sign of
chronic myeloid leukemia (CML). The quantitation of BCR-ABL1 messenger RNA is …

Standardization of molecular monitoring of CML: results and recommendations from the European treatment and outcome study

HE White, M Salmon, F Albano, CSA Andersen… - Leukemia, 2022 - nature.com
Standardized monitoring of BCR:: ABL1 mRNA levels is essential for the management of
chronic myeloid leukemia (CML) patients. From 2016 to 2021 the European Treatment and …

Standardization of molecular monitoring for chronic myeloid leukemia in Latin America using locally produced secondary cellular calibrators

MS Ruiz, M Medina, I Tapia, J Mordoh, NCP Cross… - Leukemia, 2016 - nature.com
Residual disease in chronic myeloid leukemia (CML) patients undergoing therapy with
tyrosine kinase inhibitors (TKIs) is measured by assessing the quantity of transcripts of the …

[HTML][HTML] Cartridge-based automated BCR-ABL1 mRNA quantification: solving the issues of standardization, at what cost?

JM Cayuela, E Macintyre, M Darlington… - …, 2011 - ncbi.nlm.nih.gov
Background Molecular monitoring of chronic myeloid leukemia patients treated with tyrosine
kinase inhibitors is essential for therapeutic stratification. Inter-laboratory reproducibility is …

Measurement of BCR‐ABL1 by RT‐qPCR in chronic myeloid leukaemia: findings from an International EQA Programme

S Scott, D Travis, L Whitby, J Bainbridge… - British Journal of …, 2017 - Wiley Online Library
Sequential measurement of BCR‐ABL 1 mRNA levels by reverse transcription quantitative
polymerase chain reaction (RT‐qPCR) is embedded in the management of patients with …

Establishment of a standardized multiplex assay with the analytical performance required for quantitative measurement of BCR–ABL1 on the international reporting …

JT Brown, W Laosinchai-Wolf, JB Hedges… - Blood cancer …, 2011 - nature.com
Accurate and standardized methods for the quantitative measurement of BCR–ABL1 are a
prerequisite for monitoring of treatment response in t (9; 22)-positive leukemia. Here, we …