Patient-derived cell lines and animal models have proven invaluable for the understanding
of human intestinal diseases and for drug development although both inherently comprise …

Precision medicine emerges as a new approach that takes into account individual variability.
Successful realization of precision medicine requires disease models that are able to …

Organoid technology allows the expansion of primary epithelial cells from normal and
diseased tissues, providing a unique model for human (patho) biology. In a three …

Organoids represent one of the most important advancements in the field of stem cells
during the past decade. They are three-dimensional in vitro culturing models that originate …

Organoids are in vitro–cultured three-dimensional structures that recapitulate key aspects of
in vivo organs. They can be established from pluripotent stem cells and from adult stem …

Abstract 3D culture has allowed the initiation and expansion of organ-like structures, called
organoids, from either tissue-resident adult stem cells or pluripotent stem cells. Today …

Recent advances in our understanding of the intestinal stem cell niche and the role of key
signaling pathways on cell growth and maintenance have allowed the development of fully …

Insights into the stem cell niche have allowed researchers to cultivate adult tissue stem cells
as organoids that display structural and phenotypic features of healthy and diseased …

Organoids are 3D in vitro culture systems derived from self-organizing stem cells. They can
recapitulate the in vivo architecture, functionality, and genetic signature of original tissues …

Digestive system diseases arise primarily through the interplay of genetic and environmental
influences; there is an urgent need in elucidating the pathogenic mechanisms of these …