[HTML][HTML] The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons
MK Lobo, EJ Nestler - Frontiers in neuroanatomy, 2011 - frontiersin.org
The striatum plays a key role in mediating the acute and chronic effects of addictive drugs,
with drugs of abuse causing long-lasting molecular and cellular alterations in both dorsal …
with drugs of abuse causing long-lasting molecular and cellular alterations in both dorsal …
The ins and outs of the striatum: role in drug addiction
Addiction is a chronic relapsing disorder characterized by the loss of control over drug
intake, high motivation to obtain the drug, and a persistent craving for the drug …
intake, high motivation to obtain the drug, and a persistent craving for the drug …
[HTML][HTML] Transcriptional and anatomical diversity of medium spiny neurons in the primate striatum
Medium spiny neurons (MSNs) constitute the vast majority of striatal neurons and the
principal interface between dopamine reward signals and functionally diverse cortico-basal …
principal interface between dopamine reward signals and functionally diverse cortico-basal …
Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways)
Cocaine exposure causes enduring neuroadaptations in ventral striatum, or nucleus
accumbens (NAc), an area critically involved in reward learning and relapse of drug …
accumbens (NAc), an area critically involved in reward learning and relapse of drug …
Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization
Dorsal striatum is important for the development of drug addiction; however, a precise
understanding of the roles of striatopallidal (indirect) and striatonigral (direct) pathway …
understanding of the roles of striatopallidal (indirect) and striatonigral (direct) pathway …
[HTML][HTML] Dopamine regulation of lateral inhibition between striatal neurons gates the stimulant actions of cocaine
Striatal medium spiny neurons (MSNs) form inhibitory synapses on neighboring striatal
neurons through axon collaterals. The functional relevance of this lateral inhibition and its …
neurons through axon collaterals. The functional relevance of this lateral inhibition and its …
Distinct synaptic strengthening of the striatal direct and indirect pathways drives alcohol consumption
Background Repeated exposure to addictive drugs or alcohol triggers glutamatergic and
gamma-aminobutyric acidergic (GABAergic) plasticity in many neuronal populations. The …
gamma-aminobutyric acidergic (GABAergic) plasticity in many neuronal populations. The …
[HTML][HTML] Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion
C Soares-Cunha, NAP de Vasconcelos… - Molecular …, 2020 - nature.com
Deficits in decoding rewarding (and aversive) signals are present in several
neuropsychiatric conditions such as depression and addiction, emphasising the importance …
neuropsychiatric conditions such as depression and addiction, emphasising the importance …
[HTML][HTML] Glutamatergic synaptic plasticity in the mesocorticolimbic system in addiction
AN van Huijstee, HD Mansvelder - Frontiers in cellular neuroscience, 2015 - frontiersin.org
Addictive drugs remodel the brain's reward circuitry, the mesocorticolimbic dopamine (DA)
system, by inducing widespread adaptations of glutamatergic synapses. This drug-induced …
system, by inducing widespread adaptations of glutamatergic synapses. This drug-induced …
[HTML][HTML] Distribution and compartmental organization of GABAergic medium-sized spiny neurons in the mouse nucleus accumbens
G Gangarossa, J Espallergues… - Frontiers in neural …, 2013 - frontiersin.org
The nucleus accumbens (NAc) is a critical brain region involved in many reward-related
behaviors. The NAc comprises major compartments the core and the shell, which …
behaviors. The NAc comprises major compartments the core and the shell, which …