Postoperative complications reduce adjuvant chemotherapy use in resectable pancreatic cancer

RP Merkow, KY Bilimoria, JS Tomlinson… - Annals of …, 2014 - journals.lww.com
Objective: To assess the impact of postoperative complications on the receipt of adjuvant
chemotherapy. Background: Randomized trials have demonstrated that adjuvant …

Completion of adjuvant chemotherapy after upfront surgical resection for pancreatic cancer is uncommon yet associated with improved survival

AM Altman, K Wirth, S Marmor, E Lou, K Chang… - Annals of surgical …, 2019 - Springer
Background Multiple trials have demonstrated a survival benefit for adjuvant chemotherapy
after resection of pancreatic adenocarcinoma. This study aimed to identify the rate for …

The impact of postoperative complications on the administration of adjuvant therapy following pancreaticoduodenectomy for adenocarcinoma

W Wu, J He, JL Cameron, M Makary, K Soares… - Annals of surgical …, 2014 - Springer
Background The impact of postoperative complications on the administration of adjuvant
therapy following pancreaticoduodenectomy (PD) for adenocarcinoma is still unclear …

Survival after resection of pancreatic adenocarcinoma: results from a single institution over three decades

JM Winter, MF Brennan, LH Tang… - Annals of surgical …, 2012 - Springer
Background Randomized trials have demonstrated a benefit associated with adjuvant
therapy for pancreatic cancer, and retrospective studies have demonstrated improvements …

Management of patients with pancreatic adenocarcinoma: national trends in patient selection, operative management, and use of adjuvant therapy

SC Mayo, MM Gilson, JM Herman, JL Cameron… - Journal of the American …, 2012 - Elsevier
BACKGROUND: Surgical resection remains the only potentially curative option for patients
with pancreatic adenocarcinoma (PAC). Advances in surgical technique and perioperative …

The use of adjuvant chemotherapy for pancreatic cancer varies widely between hospitals: a nationwide population‐based analysis

MJ Bakens, LG van der Geest, M van Putten… - Cancer …, 2016 - Wiley Online Library
Adjuvant chemotherapy after pancreatoduodenectomy for pancreatic cancer is currently
considered standard of care. In this nationwide study, we investigated which characteristics …

Association of timing of adjuvant therapy with survival in patients with resected stage I to II pancreatic cancer

SJ Ma, OT Oladeru, JA Miccio, AJ Iovoli… - JAMA network …, 2019 - jamanetwork.com
Importance Surgery followed by adjuvant chemotherapy or chemoradiation is widely used to
treat resectable pancreatic cancer. Although studies suggest initiation of adjuvant therapy …

Neoadjuvant therapy versus upfront resection for pancreatic cancer: the actual spectrum and clinical burden of postoperative complications

G Marchegiani, S Andrianello, C Nessi… - Annals of Surgical …, 2018 - Springer
Background Neoadjuvant therapy (NAT) is used for borderline-resectable or locally
advanced pancreatic cancer (PDAC) and exhibits promising results in terms of pathological …

Does the use of neoadjuvant therapy for pancreatic adenocarcinoma increase postoperative morbidity and mortality rates?

AB Cooper, AD Parmar, TS Riall, BL Hall… - Journal of …, 2015 - Elsevier
Introduction The impact of neoadjuvant therapy on postpancreatectomy complications is
inadequately described. Methods Data from the NSQIP Pancreatectomy Demonstration …

Efficacy of perioperative chemotherapy for resectable pancreatic adenocarcinoma: a phase 2 randomized clinical trial

DPS Sohal, M Duong, SA Ahmad, NS Gandhi… - JAMA …, 2021 - jamanetwork.com
Importance Clinical outcomes after curative treatment of resectable pancreatic ductal
adenocarcinoma (PDA) remain suboptimal. To assess the potential of early control of …