Depression and anxiety are psychiatric illnesses that are major burdens on society and
affect as much as 7% of the world's population. Here we review common approaches used …

Recent hypotheses suggest that depression may involve an inability to mount adaptive
structural changes in key neuronal networks. In particular, the addition of new neurons …

Accumulating evidence implicates hippocampal neurogenesis in the pathophysiology of
depression. Psychosocial stress reduces neurogenesis in rodents, whereas chronic …

Adult hippocampal neurogenesis, the birth of new neurons in the dentate gyrus of the adult
brain, can be regulated by stress and antidepressant treatment, and has consistently been …

The mounting evidence for neurogenesis in the adult hippocampus has fundamentally
challenged the traditional view of brain development. The intense search for clues as to the …

The hippocampus is one of several limbic brain structures implicated in the pathophysiology
and treatment of mood disorders. Preclinical and clinical studies demonstrate that stress and …

There is a growing body of evidence that neural stem cells reside in the adult central
nervous system where neurogenesis occurs throughout lifespan. Neurogenesis concerns …

Depression and anxiety are psychiatric illnesses that are major burdens in society and affect
as much as 7% of the world's population. The heterogeneous nature of depression suggests …

Adult hippocampal neurogenesis is increased by antidepressants, and is required for some
of their behavioral effects. However, it remains unclear whether expanding the population of …

Since its discovery in mammals, adult neurogenesis, the process of generating functional
neurons from neural progenitor cells in the adult brain, has inspired numerous animal …