Immunopotentiator-loaded polymeric microparticles as robust adjuvant to improve vaccine efficacy

W Zhang, L Wang, T Yang, Y Liu, X Chen, Q Liu… - Pharmaceutical …, 2015 - Springer
Purpose Adjuvants are required to ensure the efficacy of subunit vaccines. Incorporating
molecular immunopotentiators within particles could overcome drawbacks of molecular …

Combination of immune stimulating adjuvants with poly (lactide-co-glycolide) microspheres enhances the immune response of vaccines

A Salvador, M Igartua, RM Hernández, JL Pedraz - Vaccine, 2012 - Elsevier
The development of vaccines that generate mixed humoral and cellular immune responses
is a challenge in vaccinology. Poly (lactide-co-glycolide) microspheres are vaccine …

Time course study of the antigen-specific immune response to a PLGA microparticle vaccine formulation

Q Wang, MT Tan, BP Keegan, MA Barry, MJ Heffernan - Biomaterials, 2014 - Elsevier
Microparticle-based vaccine delivery systems are known to promote enhanced immune
responses to protein antigens and can elicit TH 1-biased responses when used in …

Adjuvanticity regulation by biodegradable polymeric nano/microparticle size

J Jia, W Zhang, Q Liu, T Yang, L Wang… - Molecular …, 2017 - ACS Publications
Polymeric nano/microparticles as vaccine adjuvants have been researched in experimental
and clinical studies. A more profound understanding of how the physicochemical properties …

Non-carrier nanoparticles adjuvant modular protein vaccine in a particle-dependent manner

A Seth, FK Ritchie, N Wibowo, LHL Lua… - PloS one, 2015 - journals.plos.org
Nanoparticles are increasingly used to adjuvant vaccine formulations due to their
biocompatibility, ease of manufacture and the opportunity to tailor their size, shape, and …

[PDF][PDF] Navigating the landscape of adjuvants for subunit vaccines: Recent advances and future perspectives

FL Orosco, LM Espiritu - Int. J. Appl. Pharmaceut, 2024 - pdfs.semanticscholar.org
The development of effective subunit vaccines relies on the incorporation of adjuvants to
enhance immune responses and improve vaccine efficacy. This paper provides a …

Comparative study of acetalated-dextran microparticle fabrication methods for a clinically translatable subunit-based influenza vaccine

ES Pena, CJ Batty, DA Hendy, S Yang… - International Journal of …, 2024 - Elsevier
The most common influenza vaccines are inactivated viruses produced in chicken eggs,
which is a time-consuming production method with variable efficacy due to mismatches of …

Influence of particle size, an elongated particle geometry, and adjuvants on dendritic cell activation

R Mathaes, G Winter, TJ Siahaan, A Besheer… - European Journal of …, 2015 - Elsevier
Modern subunit vaccines have many benefits compared to live vaccines such as convenient
and competitive large scale production, better reproducibility and safety. However, the poor …

Polycation-decorated PLA microspheres induce robust immune responses via commonly used parenteral administration routes

X Chen, L Wang, Q Liu, J Jia, Y Liu, W Zhang… - International …, 2014 - Elsevier
Recombinant viral subunit-based vaccines have gained increasing attention due to their
enhanced safety over the classic live-attenuated or inactivated vaccines. The low …

Rational design of polymer‐based particulate vaccine adjuvants

J Huete‐Carrasco, RI Lynch, RW Ward… - European Journal of …, 2024 - Wiley Online Library
Vaccination is considered one of the major milestones in modern medicine, facilitating the
control and eradication of life‐threatening infectious diseases. Vaccine adjuvants are a key …