[HTML][HTML] iNKT cells induce FGF21 for thermogenesis and are required for maximal weight loss in GLP1 therapy
Adipose-resident invariant natural killer T (iNKT) cells are key players in metabolic
regulation. iNKT cells are innate lipid sensors, and their activation, using their prototypic …
regulation. iNKT cells are innate lipid sensors, and their activation, using their prototypic …
Activation of invariant natural killer T cells stimulates adipose tissue remodeling via adipocyte death and birth in obesity
In obesity, adipose tissue undergoes dynamic remodeling processes such as adipocyte
hypertrophy, hypoxia, immune responses, and adipocyte death. However, whether and how …
hypertrophy, hypoxia, immune responses, and adipocyte death. However, whether and how …
[HTML][HTML] Distinct iNKT cell populations use IFNγ or ER stress-induced IL-10 to control adipose tissue homeostasis
Adipose tissue invariant natural killer T (iNKT) cells are phenotypically different from other
iNKT cells because they produce IL-10 and control metabolic homeostasis. Why that is the …
iNKT cells because they produce IL-10 and control metabolic homeostasis. Why that is the …
[HTML][HTML] Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production
Invariant natural killer T (iNKT) cells are evolutionarily conserved innate T cells that
influence inflammatory responses. We have shown that iNKT cells, previously thought to be …
influence inflammatory responses. We have shown that iNKT cells, previously thought to be …
Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice
L Wu, VV Parekh, CL Gabriel… - Proceedings of the …, 2012 - National Acad Sciences
Obesity triggers a low-grade systemic inflammation, which plays an important role in the
development of obesity-associated metabolic diseases. In searching for links between lipid …
development of obesity-associated metabolic diseases. In searching for links between lipid …
Adipose invariant natural killer T cells
L Lynch - Immunology, 2014 - Wiley Online Library
Adipose tissue is a dynamic organ that makes up a substantial proportion of the body; in
severe obesity it can account for 50% of body mass. Details of the unique immune system …
severe obesity it can account for 50% of body mass. Details of the unique immune system …
[HTML][HTML] Natural killer T cells in adipose tissue prevent insulin resistance
HS Schipper, M Rakhshandehroo… - The Journal of …, 2012 - Am Soc Clin Investig
Lipid overload and adipocyte dysfunction are key to the development of insulin resistance
and can be induced by a high-fat diet. CD1d-restricted invariant natural killer T (iNKT) cells …
and can be induced by a high-fat diet. CD1d-restricted invariant natural killer T (iNKT) cells …
[HTML][HTML] IL-6/Stat3-dependent induction of a distinct, obesity-associated NK cell subpopulation deteriorates energy and glucose homeostasis
Natural killer (NK) cells contribute to the development of obesity-associated insulin
resistance. We demonstrate that in mice obesity promotes expansion of a distinct, interleukin …
resistance. We demonstrate that in mice obesity promotes expansion of a distinct, interleukin …
[HTML][HTML] Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity
H Wang, L Shen, X Sun, F Liu, W Feng, C Jiang… - Nature …, 2019 - nature.com
Pathogenic factors driving obesity to type 2 diabetes (T2D) are not fully understood. Group 1
innate lymphoid cells (ILC1s) are effectors of innate immunity and enriched in inflamed …
innate lymphoid cells (ILC1s) are effectors of innate immunity and enriched in inflamed …
[HTML][HTML] Cdkn2a deficiency promotes adipose tissue browning
Objectives Genome-wide association studies have reported that DNA polymorphisms at the
CDKN2A locus modulate fasting glucose in human and contribute to type 2 diabetes (T2D) …
CDKN2A locus modulate fasting glucose in human and contribute to type 2 diabetes (T2D) …