Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
DIAbetes Genetics Replication And Meta-analysis … - Nature …, 2014 - nature.com
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we
aggregated published meta-analyses of genome-wide association studies (GWAS) …
aggregated published meta-analyses of genome-wide association studies (GWAS) …
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
A Mahajan, CN Spracklen, W Zhang, MCY Ng… - Nature …, 2022 - nature.com
We assembled an ancestrally diverse collection of genome-wide association studies
(GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls …
(GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls …
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
JS Kooner, D Saleheen, X Sim, J Sehmi, W Zhang… - Nature …, 2011 - nature.com
We carried out a genome-wide association study of type-2 diabetes (T2D) in individuals of
South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and …
South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and …
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Genome-wide association (GWA) studies have identified multiple loci at which common
variants modestly but reproducibly influence risk of type 2 diabetes (T2D),,,,,,,,,,. Established …
variants modestly but reproducibly influence risk of type 2 diabetes (T2D),,,,,,,,,,. Established …
Genome-wide association studies in type 2 diabetes
MI McCarthy, E Zeggini - Current diabetes reports, 2009 - Springer
Despite numerous candidate gene and linkage studies, the field of type 2 diabetes (T2D)
genetics had until recently succeeded in identifying few genuine disease-susceptibility loci …
genetics had until recently succeeded in identifying few genuine disease-susceptibility loci …
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes
Abstract Type 2 diabetes (T2D) is a very common disease in humans. Here we conduct a
meta-analysis of genome-wide association studies (GWAS) with~ 16 million genetic variants …
meta-analysis of genome-wide association studies (GWAS) with~ 16 million genetic variants …
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci
To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale
meta-analyses by using a custom∼ 50,000 SNP genotyping array (the ITMAT-Broad-CARe …
meta-analyses by using a custom∼ 50,000 SNP genotyping array (the ITMAT-Broad-CARe …
Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However,
little is known about the genetic risk in African Americans despite the recent identification of …
little is known about the genetic risk in African Americans despite the recent identification of …
Genome-wide association studies and type 2 diabetes
In recent years, the search for genetic determinants of type 2 diabetes (T2D) has changed
dramatically. Although linkage and small-scale candidate gene studies were highly …
dramatically. Although linkage and small-scale candidate gene studies were highly …
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
JD Cooper, DJ Smyth, AM Smiles, V Plagnol… - Nature …, 2008 - nature.com
We carried out a meta-analysis of data from three genome-wide association (GWA) studies
of type 1 diabetes (T1D), testing 305,090 SNPs in 3,561 T1D cases and 4,646 controls of …
of type 1 diabetes (T1D), testing 305,090 SNPs in 3,561 T1D cases and 4,646 controls of …
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