TCR revision is a tolerance mechanism by which self-reactive TCRs expressed by mature
CD4+ peripheral T cells are replaced by receptors encoded by genes generated by post …

Abstract Mature CD4+ Vβ5+ T cells that recognize a peripherally expressed endogenous
superantigen are tolerized either by deletion or TCR revision. In Vβ5 transgenic mice, this …

T‐cell receptor (TCR) revision is a process of tolerance induction by which peripheral T cells
lose surface expression of an autoreactive TCR, reinduce expression of the recombinase …

Abstract CD4+ Vβ5+ T cells enter one of two tolerance pathways after recognizing a
peripherally expressed superantigen encoded by an endogenous retrovirus. One pathway …

In Vβ5 transgenic mice, the age-dependent accumulation of Vβ5− CD4+ T cells expressing
endogenous Vβ elements represents an exception to the rule of strict allelic exclusion at the …

Abstract CD4+ Vβ5+ peripheral T cells in C57BL/6 mice respond to encounter with a
peripherally expressed endogenous superantigen by undergoing either deletion or TCR …

To investigate the consequences of the simultaneous expression in progenitor cells of a
TCRγδ and a pre-TCR on αβ/γδ lineage commitment, we have forced expression of …

In Vβ5 transgenic mice, mature Vβ5+ CD4+ T cells are tolerized upon recognition of a self
Ag, encoded by a defective endogenous retrovirus, whose expression is confined to the …

In jawed vertebrates, adaptive immunity depends on the process of V (D) J recombination
creating vast numbers of T and B lymphocytes that each expresses unique Ag receptors of …

V (D) J recombination is a mechanism peculiar to the somatic rearrangement of antigen
receptor genes. It requires both expression of the RAG-1 and RAG-2 recombinases and …