Background: Studies of related individuals have consistently demonstrated notable familial
aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable …

The familial aggregation indicated the inheritance of cancer risk. Recent genome‐wide
association studies (GWASs) have identified a number of common single‐nucleotide …

Quantifying the genetic correlation between cancers can provide important insights into the
mechanisms driving cancer etiology. Using genome-wide association study summary …

Background: Many cancers share specific genetic risk factors, including both rare high-
penetrance mutations and common SNPs identified through genome-wide association …

To find additional susceptibility loci for lung cancer, we tested promising associations from
our previous genome-wide association study (GWAS) of lung cancer in the Chinese …

Although several lung cancer susceptibility loci have been identified, much of the heritability
for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European …

Tobacco smoke is the major environmental risk factor underlying lung carcinogenesis.
However, approximately one-tenth smokers develop lung cancer in their lifetime indicating …

Deciphering the shared genetic basis of distinct cancers has the potential to elucidate
carcinogenic mechanisms and inform broadly applicable risk assessment efforts. Here, we …

Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women
have previously identified six susceptibility loci associated with lung cancer risk. To further …

To identify genetic variation associated with lung cancer risk, we performed a genome-wide
association analysis of 685 lung cancer cases that had a family history of two or more first or …