The innate immune system senses viral infection by recognizing a variety of viral
components (including double-stranded (ds) RNA) and triggers antiviral responses,. The …

Mammalian cells possess mechanisms to detect and defend themselves from invading
viruses. In the cytosol, the RIG-I-like receptors (RLRs), RIG-I (retinoic acid-inducible gene I; …

Retinoic-acid-inducible gene-I (RIG-I; also known as DDX58) is a cytoplasmic pathogen
recognition receptor that recognizes pathogen-associated molecular pattern (PAMP) motifs …

Intracellular double-stranded RNA (dsRNA) is a chief sign of replication for many viruses.
Host mechanisms detect the dsRNA and initiate antiviral responses. In this report, we …

Double-stranded RNA (dsRNA) produced during viral replication is believed to be the critical
trigger for activation of antiviral immunity mediated by the RNA helicase enzymes retinoic …

Traditional functions of DExD/H-box helicases are concerned with RNA metabolism; they
have been shown to play a part in nearly every cellular process that involves RNA. On the …

Innate and antigen‐specific antiviral immunity are triggered by immunorecognition of viral
nucleic acids. The helicase retinoic acid‐inducible gene I (RIG‐I)(also known as DDX58) is …

TLRs detect several classes of virus-associated molecules, such as ssRNA, CpG-DNA and
dsRNA, and transduce signals leading to the production of IFN. Recently discovered …

The structural basis for the distinction of viral RNA from abundant self RNA in the cytoplasm
of virally infected cells is largely unknown. We demonstrated that the 5′-triphosphate end of …

Intracellular pattern recognition receptors MDA5, RIG-I, and LGP2 are essential components
of the cellular response to virus infection and are homologous to the DEXH box subfamily of …