Background We previously reported that one-third of HIV-positive adults requiring medical
admission to a South African district hospital had laboratory-confirmed tuberculosis (TB) and …

Background Autopsy studies of HIV/AIDS-related hospital deaths in sub-Saharan Africa
reveal frequent failure of pre-mortem diagnosis of tuberculosis (TB), which is found in 34 …

Background Current diagnostics for HIV-associated tuberculosis are suboptimal, with
missed diagnoses contributing to high hospital mortality and approximately 374 000 annual …

Background Rapid diagnostic tests are urgently needed to mitigate HIV-associated
tuberculosis (TB) mortality. We evaluated diagnostic accuracy of the rapid urine …

Background Hospitals in sub-Saharan Africa are inundated with HIV-infected patients and
tuberculosis (TB) is the commonest opportunistic infection in this sub-group. Up to one third …

Background Determine-TB LAM assay is a urine point-of-care test useful for TB diagnosis in
HIV-positive patients. We assessed the incremental diagnostic yield of adding LAM to …

HIV-associated disseminated TB (tuberculosis) has been under-recognised and poorly
characterised. Blood culture is the gold-standard diagnostic test, but is expensive, slow, and …

Background HIV-associated tuberculosis is difficult to diagnose and results in high mortality.
Frequent extra-pulmonary presentation, inability to obtain sputum, and paucibacillary …

Background The diagnostic accuracy of sputum smear microscopy and routine chest
radiology for HIV-associated tuberculosis is poor, and culture-based diagnosis is slow …

Background Tuberculosis is a major health concern in several countries, and effective
diagnostic algorithms for use in human immunodeficiency virus (HIV)–positive patients are …