While the mammalian macrophage phenotypes have been intensively studied in vitro, the
dynamic of their phenotypic polarization has never been investigated in live vertebrates. We …

The role of macrophages during regeneration in zebrafish has been well-documented.
Nevertheless, new evidence indicates that zebrafish macrophages are a heterogeneous …

Macrophages are phagocytic cells from the innate immune system, which forms the first line
of host defense against invading pathogens. These highly dynamic immune cells can adopt …

Zebrafish have emerged as a powerful model system to study leukocyte recruitment and
inflammation. Here we characterize the morphology and function of inflammatory …

Transgenic labeling of innate immune cell lineages within the larval zebrafish allows for real-
time, in vivo analyses of microbial pathogenesis within a vertebrate host. To date, labeling of …

Macrophages are found across all vertebrate species, reside in virtually all animal tissues,
and play critical roles in host protection and homeostasis. Various mechanisms determine …

Tissue-resident macrophages (TRMs) and dendritic cells (DCs) are highly heterogeneous
and essential for immunity, tissue regeneration, and homeostasis maintenance. Here, we …

Zebrafish (Danio rerio), largely used as a model for studying developmental processes, has
also emerged as a valuable system for modelling human inflammatory diseases. However …

Phagocytosis provides a critical first line of defense against invading pathogens.
Engagement of particles through receptor-mediated binding precedes internalization and …

The outcome following injury can be healing, scarring or regeneration, all of which initiate
within a resolving inflammatory response. Regeneration, comprising the complete …