Squamous cell carcinomas of the head and neck (HNSCC) arise from mucosal keratinocytes
of the upper aero-digestive tract. Despite a common cell of origin and similar driver-gene …

Development of head and neck squamous cell carcinoma (HNSCC) is characterized by
accumulation of mutations in several oncogenes and tumor suppressor genes. We have …

Genomic alterations are a driving force in the multistep process of head and neck cancer
(HNC) and result from the interaction of exogenous environmental exposures and …

Smoking has historically been recognized as a negative prognostic factor in head and neck
squamous cell carcinoma (HNSCC). This study aimed to assess the mutational differences …

Background Tobacco and alcohol consumption are risk factors for head and neck squamous
cell carcinoma (HNSCC). Recently, whole-exome sequencing clarified that smoking …

Background Human papillomavirus (HPV)-driven oropharyngeal cancer (OPC) patients are
characterised by a better prognosis than their HPV-negative counterparts. However, this …

Background Evidence suggests the incidence of oral tongue squamous cell carcinoma is
increasing in young patients, many who have no history of tobacco use. Methods We …

Simple Summary A clinically distinct cohort of non-smoking non-drinking patients who
develop oral cavity squamous cell carcinomas has been identified, with previous work …

Although tobacco use is an independent adverse prognostic feature in HPV (+)
oropharyngeal squamous cell carcinoma (OPSCC), the biologic features associated with …

Background Tobacco smoking creates DNA damage, inducing mutations and potentially
altering the tumor immune microenvironment. These types of genetic and immune …