Digoxin is a cardiac glycoside used as drug in case of heart problems, including congestive
heart failure, atrial fibrillation or flutter, and certain cardiac arrhythmias. It has a very narrow …

Digoxin is the oldest cardiac medication used in contemporary medicine. With a complex
pharmacokinetic profile and narrow therapeutic index, its use in managing patients with …

Because of the common use of digoxin and because of its narrow therapeutic index, digoxin
toxicity has been prevalent historically and, therefore, most clinicians are well aware of the …

The intestinal absorption of digoxin is essentially a passive non-saturable diffusion process,
although a saturable carrier-mediated component also plays an important role. The …

Digoxin remains one of the most commonly prescribed of all cardiac medications. The main
indications for digoxin usage include atrial fibrillation and heart failure; both these conditions …

Digoxin usage has decreased in the treatment of congestive heart failure and atrial
fibrillation as a result of its inferiority to beta-adrenergic inhibitors and agents that interfere …

After 200 years of use, digitalis still appears to have a place in our armamentarium for heart
failure and atrial fibrillation despite the proven survival benefits with ACE inhibitors and β …

OBJECTIVE: To evaluate the relationship of the therapeutic serum digoxin concentration
(SDC) range (0.5–2 ng/mL, as recommended in previous clinical studies) with the incidence …

Context. Digoxin-specific antibody fragments (digoxin-Fab) are widely regarded as a safe
and effective treatment for the management of acute and chronic digoxin poisoning …

About 70 to 80% of an oral dose of digoxin is absorbed, mainly in the proximal part of the
small intestine. The degree of binding to serum albumin is 20 to 30%. Digoxin is extensively …