Background Germline mutations in MSH6 account for 10%–20% of Lynch syndrome
colorectal cancers caused by hereditary DNA mismatch repair gene mutations. Because …

Context Providing accurate estimates of cancer risks is a major challenge in the clinical
management of Lynch syndrome. Objective To estimate the age-specific cumulative risks of …

Background Lynch syndrome is a highly penetrant cancer predisposition syndrome caused
by germline mutations in DNA mismatch repair (MMR) genes. We estimated the risks of …

Purpose Pathogenic variants affecting MLH1, MSH2, MSH6, and PMS2 cause Lynch
syndrome and result in different but imprecisely known cancer risks. This study aimed to …

Background Existing clinical practice guidelines for carriers of pathogenic variants of DNA
mismatch repair genes (Lynch syndrome) are based on the mean age-specific cumulative …

Purpose Lynch syndrome due to pathogenic variants in the DNA mismatch repair genes
MLH1, MSH2, and MSH6 is predominantly associated with colorectal and endometrial …

Purpose To determine whether cancer risks for carriers and noncarriers from families with a
mismatch repair (MMR) gene mutation are increased above the risks of the general …

ContextHereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch
syndrome, is caused by mutations in the mismatch repair genes and confers an …

Purpose Patients with Lynch syndrome are at high risk for colon and endometrial cancer, but
also at an elevated risk for other less common cancers. The purpose of this retrospective …

ContextIdentifying families at high risk for the Lynch syndrome (ie, hereditary nonpolyposis
colorectal cancer) is critical for both genetic counseling and cancer prevention. Current …