BACKGROUND & AIMS: Transforming growth factor (TGF)-β–activated kinase 1 (TAK1) is
activated in different cytokine signaling pathways. Deletion of Tak1 from hepatocytes results …

TGF-β–activated kinase 1 (TAK1) is a MAP3K family member that activates NF-κB and JNK
via Toll-like receptors and the receptors for IL-1, TNF-α, and TGF-β. Because the TAK1 …

Transforming growth factor beta (TGF‐β) signaling activates Smad‐and TGF‐β‐activated
kinase 1 (TAK1)‐dependent signaling to regulate cell survival, proliferation, fibrosis, and …

BACKGROUND & AIMS: The profibrogenic role of transforming growth factor (TGF)-β in liver
has mostly been attributed to hepatic stellate cell activation and excess matrix synthesis …

Transforming growth factor β (TGF-β) is cytostatic towards damage-induced compensatory
hepatocyte proliferation. This function is frequently lost during hepatocarcinogenesis …

The MAP kinase kinase kinase TGFβ-activated kinase 1 (TAK1) is activated by TLRs, IL-1,
TNF, and TGFβ and in turn activates IKK-NF-κB and JNK, which regulate cell survival …

Abstract TGF-β-activated kinase 1 (TAK1 or MAP3K7) is an intracellular hub molecule that
regulates both nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) …

Hepatocyte death is associated with liver inflammation, fibrosis and hepatocellular
carcinoma (HCC). Damaged cells trigger inflammation through activation of Toll‐like …

Chronic insult and persistent injury can cause liver inflammation, fibrosis, and
carcinogenesis; it can also be associated with metabolic disorders. Identification of critical …

Smad family proteins Smad2 and Smad3 are activated by transforming growth factor β (TGF-
β)/activin/nodal receptors and mediate transcriptional regulation. Although differential …